Pereira Nayara Fernanda, Silva Paula Verona Ragusa da, Fukuoka Cíntia Yuki, Michel-Crosato Edgard, Gonçalves Alyne Simões, Alves Fábio Abreu, Vieira Garles Miller Matias, Biazevic Maria Gabriela Haye
Universidade de São Paulo - USP, School of Dentistry, Community Dentistry Department, São Paulo, SP, Brazil.
Universidade de São Paulo - USP, School of Dentistry, Stomatology Department, São Paulo, SP, Brazil.
Braz Oral Res. 2018 Jul 23;32:e78. doi: 10.1590/1807-3107BOR-2018.vol32.0078.
Oral mucositis is a painful condition that occurs in patients who have undergone haematopoietic stem-cell transplantation (HSCT) and has a huge impact on their quality of life. The objective of this study was to examine the extent to which interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-α) are associated with oral health quality of life among patients who underwent HSCT. A. C. Camargo Cancer Center patients were evaluated over 20 months at 4 different time-points: a) at patient admission (M1); b) on the day of infusion of HSC (M2); c) 12 and 20 days after the first day of the conditioning regimen for autologous and allogeneic transplantation, respectively (M3); and d) 30 days after the first day of the conditioning regimen (M4). Mucositis clinical evaluations were performed using World Health Organization (WHO) criteria. Oral health quality of life was measured using the Oral Health Impact Profile short form (OHIP-14), Oral Mucositis Quality of Life (OMQoL) and Patient-Reported Oral Mucositis Symptom (PROMS) scales. Correlations between clinical data and quality of life scores were examined. STATA 11.0 was used to perform the statistical analyses (5% level of significance). Eighty-two patients participated in the study; 62.2% were male, 28.05% had multiple myeloma, and the mean age was 48.49 years (SD 13.76). Higher scores (worse quality of life) were observed as mucositis scores increased, but the results were not significant. The OMQoL had a high correlation with OHIP-14 (0.8377), but the correlation between the PROMS scale and the OHIP-14 was lower (0.6643). Higher concentrations of IL-6 and TNF-α were associated with worse quality of life, according to all indices (p < 0.05). Oral mucositis was associated with quality of life scores (p < 0.01).
口腔黏膜炎是一种发生在接受造血干细胞移植（HSCT）患者身上的疼痛性病症，对他们的生活质量有巨大影响。本研究的目的是探讨白细胞介素-6（IL-6）和肿瘤坏死因子α（TNF-α）与接受HSCT患者口腔健康生活质量的关联程度。对A.C.卡马戈癌症中心的患者进行了为期20个月的评估，共4个不同时间点：a）患者入院时（M1）；b）造血干细胞输注当天（M2）；c）自体和异体移植预处理方案第一天分别后的12天和20天（M3）；d）预处理方案第一天后的30天（M4）。使用世界卫生组织（WHO）标准进行黏膜炎临床评估。使用口腔健康影响简表（OHIP-14）、口腔黏膜炎生活质量（OMQoL）和患者报告的口腔黏膜炎症状（PROMS）量表来测量口腔健康生活质量。检查临床数据与生活质量评分之间的相关性。使用STATA 11.0进行统计分析（显著性水平为5%）。82名患者参与了研究；62.2%为男性，28.05%患有多发性骨髓瘤，平均年龄为48.49岁（标准差13.76）。随着黏膜炎评分增加，观察到更高的分数（更差的生活质量），但结果不显著。OMQoL与OHIP-14具有高度相关性（0.8377），但PROMS量表与OHIP-14之间的相关性较低（0.6643）。根据所有指标，IL-6和TNF-α的浓度较高与较差的生活质量相关（p<0.05）。口腔黏膜炎与生活质量评分相关（p<0.01）。
