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A DNA glycosylase for oxidized thymine residues in Drosophila melanogaster.

作者信息

Breimer L H

出版信息

Biochem Biophys Res Commun. 1986 Jan 14;134(1):201-4. doi: 10.1016/0006-291x(86)90547-4.

DOI:10.1016/0006-291x(86)90547-4
PMID:3004428
Abstract

A DNA glycosylase activity which excises fragmented thymine residues has been identified in cell extracts from Drosophila melanogaster embryos. The enzyme has an apparent Mr = 40,000, acts preferentially on double-stranded polydeoxyribonucleotide substrate and requires no co-factors. The DNA glycosylase presumably acts in excision-repair of pyrimidines damaged by hydroxyl radicals and other oxidizing species. This is the first identification of a DNA glycosylase in Drosophila cells.

摘要

相似文献

1
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引用本文的文献

1
Repair of oxidative DNA damage in Drosophila melanogaster: identification and characterization of dOgg1, a second DNA glycosylase activity for 8-hydroxyguanine and formamidopyrimidines.黑腹果蝇中氧化性DNA损伤的修复：dOgg1的鉴定与特性，一种针对8-羟基鸟嘌呤和甲酰胺嘧啶的第二种DNA糖基化酶活性
Nucleic Acids Res. 2000 Dec 1;28(23):4583-92. doi: 10.1093/nar/28.23.4583.
2
Molecular cloning and functional analysis of a Schizosaccharomyces pombe homologue of Escherichia coli endonuclease III.裂殖酵母中大肠杆菌内切核酸酶III同源物的分子克隆与功能分析
Nucleic Acids Res. 1996 Sep 1;24(17):3307-12. doi: 10.1093/nar/24.17.3307.
3
Ionizing radiation-induced mutagenesis.
电离辐射诱导的诱变作用。
Br J Cancer. 1988 Jan;57(1):6-18. doi: 10.1038/bjc.1988.2.
4
A highly conserved endonuclease activity present in Escherichia coli, bovine, and human cells recognizes oxidative DNA damage at sites of pyrimidines.存在于大肠杆菌、牛和人类细胞中的一种高度保守的核酸内切酶活性可识别嘧啶位点的氧化性DNA损伤。
Mol Cell Biol. 1987 Jan;7(1):26-32. doi: 10.1128/mcb.7.1.26-32.1987.