From the Departments of Anesthesiology and Pain Management.
Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas.
Anesth Analg. 2018 Oct;127(4):e54-e56. doi: 10.1213/ANE.0000000000003675.
Patients with type 2 diabetes mellitus receiving oral hypoglycemic drugs (OHDs) are usually instructed to stop them before surgery. We hypothesize that continuing OHD preoperatively should result in lower perioperative blood glucose (BG) levels. Ambulatory surgery patients with type 2 diabetes mellitus on OHDs were randomized to continue (n = 69) or withhold (n = 73) OHDs preoperatively. Log-transformed BG levels at pre-, intra-, and postoperative periods were analyzed. Perioperative BG levels were significantly lower (mean, 138 mg/dL; 95% confidence interval, 130-146 mg/dL) in the group that continued versus the group that discontinued OHDs (mean, 156 mg/dL; 95% confidence interval, 146-167 mg/dL; P < .001).
接受口服降糖药（OHD）治疗的 2 型糖尿病患者通常在手术前被要求停止使用 OHD。我们假设术前继续使用 OHD 应该会导致更低的围手术期血糖（BG）水平。接受 OHD 治疗的 2 型糖尿病门诊手术患者被随机分为继续（n = 69）或术前停用（n = 73）OHD 组。分析了术前、术中、术后各时期的 BG 水平的对数值。与停止 OHD 的组相比（平均 156 毫克/分升；95%置信区间，146-167 毫克/分升），继续使用 OHD 的组的围手术期 BG 水平显著更低（平均 138 毫克/分升；95%置信区间，130-146 毫克/分升；P<.001）。
