Camp Jason E
Department of Chemical Sciences, University of Huddersfield, Queensgate, Huddersfield, UK.
ChemSusChem. 2018 Sep 21;11(18):3048-3055. doi: 10.1002/cssc.201801420. Epub 2018 Aug 15.
The development of green solvents is one of the key tenets of Green Chemistry as solvents account for the majority of waste stemming from the production of the chemicals on which we have all come to rely. An important class of solvents is the dipolar aprotics, which include N,N-dimethylformamide (DMF) and N-methyl-2-pyrrolidone (NMP). In addition to being derived from non-renewable resources, these solvents are also under increased regulatory pressures that will limit their industrial applications. This Concept concerns the bio-available solvent Cyrene (dihydrolevoglucosenone) as a potential replacement for toxic dipolar aprotic solvents. An emphasis is placed on examining the strengths and weaknesses of Cyrene as a solvent and is accomplished by looking at the synthesis, derivatization, and application in synthetic protocols of Cyrene. With respect to the Twelve Principles of Green Chemistry, this Concept describes a bio-available solvent that should have a disruptive effect on the use of traditional industrial dipolar aprotic solvents.
绿色溶剂的开发是绿色化学的关键原则之一，因为溶剂是我们所依赖的化学品生产过程中产生的大部分废物的来源。一类重要的溶剂是偶极非质子溶剂，包括N，N-二甲基甲酰胺（DMF）和N-甲基-2-吡咯烷酮（NMP）。这些溶剂除了来源于不可再生资源外，还面临着越来越大的监管压力，这将限制它们的工业应用。本概念涉及生物可利用溶剂环戊酮（二氢左旋葡萄糖酮）作为有毒偶极非质子溶剂的潜在替代品。重点在于研究环戊酮作为溶剂的优缺点，这通过考察其合成、衍生化以及在合成方案中的应用来实现。关于绿色化学的十二项原则，本概念描述了一种生物可利用溶剂，它应该会对传统工业偶极非质子溶剂的使用产生颠覆性影响。
