Oţelea Marina, Raşcu Agripina, Postolache Paraschiva
Rev Med Chir Soc Med Nat Iasi. 2016 Jul-Sep;120(3):497-502.
Several similarities have reported between patients suboptimal level of vitamin D and patients with Chronic Obstructive Pulmonary Disease (COPD): both conditions are more prevalent after the 6th decade and are associated with impaired defense mechanisms, with skeletal muscles dysfunction and with an early ageing process. We have reviewed the literature concerning the interrelationship between the main pathophysiological processes of both conditions, in order to emphasize the influence of vitamin D deficit on COPD development and evolution. Epidemiological, clinical and experimental data supporting this association are presented. We concluded that the identification of common pathophysiological mechanisms for the vitamin D deficiency and COPD substantiates the hypothesis of the involvement of this hormone in the chronic obstructive pulmonary disease.
已有报道称维生素D水平未达最佳状态的患者与慢性阻塞性肺疾病（COPD）患者之间存在若干相似之处：这两种情况在60岁以后更为普遍，且都与防御机制受损、骨骼肌功能障碍以及早期衰老过程有关。我们回顾了有关这两种情况主要病理生理过程之间相互关系的文献，以强调维生素D缺乏对COPD发生发展的影响。文中呈现了支持这种关联的流行病学、临床和实验数据。我们得出结论，确定维生素D缺乏和COPD的共同病理生理机制证实了这种激素参与慢性阻塞性肺疾病的假说。
