Apăvăloaie Maria-Cristina, Bararu Iris, Pleşoianu Carmen Elena, Jitaru Daniela, Dragoş Loredana, Ciocoiu Manuela, Arsenescu-Georgescu Cătălina, Bădescu Magda
Rev Med Chir Soc Med Nat Iasi. 2016 Jul-Sep;120(3):530-6.
To analyze the correlations between inflammation markers and ApoB100 and angiotensin converting enzyme (ACE) gene polymorphism and the severity of coronary artery disease (CAD).
We conducted a study in 58 patients with acute coronary syndromes (ACS) who underwent coronarography at the Iasi "Prof. Dr. George I.M. Georgescu' Institute of Cardiovascular Diseases. the patients included in the studies were selected from those who needed a coronarography for unstable angina or acute myocardial infarction. The data were uploaded and processed using the statistical functions in SPPS 18.0 at a 95% materiality threshold.
Elevated inflammation markers were found in all study patients, with small differences in distribution. None of the study patients presented ApoB100 gene mutations. As to ACE polymorphism, a predominance of genotype II in unicoronary patients and ID and DD genotypes in bicoronary and tricoronary patients was found.
The results of our study confirm the role of genetic and epigenetic factors in the severity and progression of the coronary disease, leaving room for larger and more comprehensive studies and new research perspectives.
分析炎症标志物与载脂蛋白B100（ApoB100）和血管紧张素转换酶（ACE）基因多态性之间的相关性以及它们与冠状动脉疾病（CAD）严重程度的关系。
我们对58例急性冠状动脉综合征（ACS）患者进行了一项研究，这些患者在雅西“乔治·I·M·乔治斯库教授”心血管疾病研究所接受了冠状动脉造影检查。纳入研究的患者是从因不稳定型心绞痛或急性心肌梗死而需要进行冠状动脉造影的患者中挑选出来的。数据使用SPPS 18.0中的统计功能进行上传和处理，显著性阈值为95%。
在所有研究患者中均发现炎症标志物升高，分布存在细微差异。所有研究患者均未出现ApoB100基因突变。至于ACE基因多态性，单支冠状动脉病变患者中基因型II占优势，双支和三支冠状动脉病变患者中ID和DD基因型占优势。
我们的研究结果证实了遗传和表观遗传因素在冠状动脉疾病严重程度和进展中的作用，为更大规模、更全面的研究以及新的研究视角留出了空间。
