Department of Endocrinology and Nutrition, Endocrinology and Nutrition Research Center, School of Medicine, Hospital Clinico Universitario, Valladolid, Spain.
Department of Surgery H Universitario Rio Hortega, University of Valladolid, Valladolid, Spain.
Ann Nutr Metab. 2018;73(2):106-112. doi: 10.1159/000491434. Epub 2018 Jul 25.
Omentin-1 might play a role in the pathogenesis of insulin resistance and obesity. The aim of the present study was to evaluate the influence of weight loss after biliopancreatic diversion on serum omentin-1 concentrations. Material and Methods A Caucasian population of 24 morbid obese patients was analyzed before and after 12 months of a biliopancreatic diversion surgery. Biochemical and anthropometric evaluation were realized at basal visit and at 12 months. Body weight, fat mass, waist circumferences, blood pressure, fasting blood glucose, fasting insulin, insulin resistance (HOMA-IR), lipid concentrations and omentin-1 were measured.
After bariatric surgery and in both gender groups (males vs. females); BMI, weight, fat mass, waist circumference, blood pressure, glucose , total cholesterol, LDL cholesterol, triglycerides, HOMA-IR and fasting insulin decreased in a statistical manner from basal values. Omentin-1 levels increased after bariatric surgery and in both gender the improvement was similar (males vs. females); (delta: -87.1 ± 19.0 ng/dL; p = 0.02 vs. -93.8 ± 28.1 ng/dL; p = 0.03). In the multiple regression analysis adjusted by age and sex; BMI kg/m2 (Beta -0.32: 95% CI -3.98 to -0.12) and insulin UI/L (Beta -0.41: 95% CI -8.38 to -0.16) remained in the model with basal omentin-1 levels as dependent variable. The regression model with post-surgery omentin-1 levels as dependent variable showed as independent variables BMI kg/m2 (Beta -0.13: 95% CI -7.69 to -0.09) and insulin UI/L (Beta -0.24: 95% CI -5.69 to -0.08), too.
This study showed a significant increase in omentin-1 levels after weight loss secondary biliopancreatic diversion surgery. A weak negative correlation with BMI and basal insulin levels was detected.
网膜素-1 可能在胰岛素抵抗和肥胖的发病机制中发挥作用。本研究旨在评估胆胰分流术后体重减轻对血清网膜素-1 浓度的影响。
分析了 24 例肥胖白人患者在胆胰分流术前和术后 12 个月的情况。在基线访视和 12 个月时进行生化和人体测量评估。测量体重、体脂量、腰围、血压、空腹血糖、空腹胰岛素、胰岛素抵抗（HOMA-IR）、血脂浓度和网膜素-1。
在接受减重手术后，男性和女性两组的 BMI、体重、体脂量、腰围、血压、血糖、总胆固醇、LDL 胆固醇、甘油三酯、HOMA-IR 和空腹胰岛素均从基线值呈统计学下降。术后网膜素-1水平升高，且男性和女性的改善情况相似（男性 vs. 女性）；（差值：-87.1±19.0ng/dL；p=0.02 与-93.8±28.1ng/dL；p=0.03）。在调整年龄和性别的多元回归分析中；BMIkg/m2（Beta-0.32：95%CI-3.98 至-0.12）和胰岛素 UI/L（Beta-0.41：95%CI-8.38 至-0.16）仍作为因变量的基础网膜素-1 水平的模型中的自变量。以术后网膜素-1 水平为因变量的回归模型显示，BMIkg/m2（Beta-0.13：95%CI-7.69 至-0.09）和胰岛素 UI/L（Beta-0.24：95%CI-5.69 至-0.08）作为独立变量。
本研究显示胆胰分流术后体重减轻后网膜素-1 水平显著升高。检测到与 BMI 和基础胰岛素水平呈弱负相关。
