Schliebs R, Rothe T, Bigl V
Brain Res. 1986 Jan;389(1-2):179-85. doi: 10.1016/0165-3806(86)90185-9.
The postnatal development of [3H]flunitrazepam binding to benzodiazepine receptors has been studied in the retina, lateral geniculate nucleus, superior colliculus, frontal cortex and visual cortex of the rat. In the frontal and visual cortices, binding reached the highest level at postnatal day 25 and then decreased slightly until adulthood. In the superior colliculus, the adult value of [3H]flunitrazepam binding is already reached at postnatal day 25, whereas in the retina the highest binding was found at postnatal day 50. The ontogeny of benzodiazepine binding sites in the visual regions does not essentially differ from that in other brain regions, suggesting that the appearance of [3H]flunitrazepam binding sites in the visual system is not correlated with the development of retinal function and the functional maturation of the visual system with regard to processing of light stimuli. Raising rats in complete darkness from birth until the age of 25 days resulted in significantly decreased binding levels in the lateral geniculate nucleus and in the superior colliculus by 29% and 17%, respectively, as compared to controls. [3H]Flunitrazepam binding in the other regions studied was not affected by dark-rearing. Presumably, the complete lack of visual experience interferes with the functional development of GABAergic mechanisms involved in the gating function of the subcortical visual centres for visual information transfer.
研究了大鼠视网膜、外侧膝状体、上丘、额叶皮质和视皮质中[3H]氟硝西泮与苯二氮䓬受体结合的产后发育情况。在额叶皮质和视皮质中，结合在出生后第25天达到最高水平，然后略有下降直至成年。在上丘中，[3H]氟硝西泮结合的成年值在出生后第25天就已达到，而在视网膜中，最高结合在出生后第50天被发现。视觉区域中苯二氮䓬结合位点的个体发生与其他脑区基本没有差异，这表明视觉系统中[3H]氟硝西泮结合位点的出现与视网膜功能的发育以及视觉系统在处理光刺激方面的功能成熟无关。从出生到25日龄将大鼠饲养在完全黑暗的环境中，与对照组相比，外侧膝状体和上丘中的结合水平分别显著降低了29%和17%。所研究的其他区域中[3H]氟硝西泮的结合不受暗饲养的影响。据推测，完全缺乏视觉经验会干扰参与皮层下视觉中心视觉信息传递门控功能的GABA能机制的功能发育。
