Animal Health Department, University of Cordoba, Cordoba, Spain.
Infectious Diseases Unit, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Cordoba, Spain.
Transbound Emerg Dis. 2019 Jan;66(1):66-71. doi: 10.1111/tbed.12962. Epub 2018 Jul 26.
Hepatitis E (HE) is an important emerging disease in European countries. To analyse the role of equids as potential reservoirs for HE virus (HEV), we determined the prevalence of HEV infection in 861 equines from 464 herds in Spain. HEV RNA in serum was detected in 0.4% (3/692) of horses, 1.2% (1/86) of donkeys and 3.6% (3/83) of mules. Phylogenetic analysis identified the zoonotic genotype 3 as being closely related to viral human and swine strains. In this first report on HEV in equids in Europe, we confirm the susceptibility of horses, donkeys and mules to HEV infection. The low prevalence detected indicates that equids may be considered spillover hosts rather than true reservoirs.
戊型肝炎（HE）是欧洲国家的一种重要的新兴疾病。为了分析马等动物作为戊型肝炎病毒（HEV）潜在宿主的作用，我们在西班牙的 464 个畜群中检测了 861 匹马的 HEV 感染流行率。在 692 匹马中，有 0.4%（3/692）的马、1.2%（1/86）的驴和 3.6%（3/83）的骡血清中检测到 HEV RNA。系统进化分析确定了人畜共患基因型 3 与人类和猪的病毒株密切相关。在这篇关于欧洲马属动物 HEV 的首次报告中，我们证实了马、驴和骡对 HEV 感染的易感性。检测到的低流行率表明，马等动物可能被认为是溢出宿主，而不是真正的储存宿主。
