Department of Pharmacy, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
Student Brigade Ten Team, Second Military Medical University, Shanghai 200433, China.
Chin J Nat Med. 2018 Jun;16(6):401-410. doi: 10.1016/S1875-5364(18)30073-6.
Rhododendron molle G. Don, belonging to the Ericaceae family, is a traditional Chinese medicinal plant with a wide spectrum of pharmacological effects. This paper aimed to review the phytochemistry, pharmacology and toxicology of R. molle, and to discuss the tendency of future investigations on this plant. A systematic review of literature about R. molle was carried out using resources including classic books about Chinese herbal medicine, and scientific data bases including CNKI, Pubmed, SciFinder, Scopus, and Web of Science. Over 67 compounds, including diterpenes, triterpenes, flavonoids, and lignans, had been extracted and identified from R. molle. The extracts/monomers isolated from the root, flower and fruits of this plant were used as effective agents for treating pains, inflammatory diseases, hypertension, and pest, etc. In addition, diterpenes, such as rhodojaponin III, were considered as the toxic agents associated with the toxicities of this plant. These findings will be significant for the discovery of new drugs from this plant and full utilization of R. molle.
绵马贯众，属于鳞毛蕨科植物，是一种具有广泛药理作用的传统中药。本文旨在综述绵马贯众的化学成分、药理学和毒理学研究进展，并探讨该植物未来的研究趋势。通过查阅《中华本草》等经典中草药书籍和中国知网（CNKI）、PubMed、SciFinder、Scopus 和 Web of Science 等科学数据库，对绵马贯众进行了系统的文献回顾。从绵马贯众中已提取并鉴定出 67 多种化合物，包括二萜、三萜、黄酮类和木脂素类。该植物的根、花和果实提取物/单体被用作治疗疼痛、炎症性疾病、高血压和虫害等的有效药物。此外，二萜如绵马素 III 被认为是与该植物毒性相关的毒性物质。这些发现对于从该植物中发现新药和充分利用绵马贯众具有重要意义。
