Spruijt B M, Cools A R, Ellenbroek B A, Gispen W H
Eur J Pharmacol. 1986 Jan 29;120(3):249-56. doi: 10.1016/0014-2999(86)90465-6.
ACTH-(1-24)-induced grooming was studied after administration of the peptide into the substantia nigra or intracerebroventricularly (i.c.v.). The modulation of dopamine receptors in neostriatum (with haloperidol and apomorphine) and nucleus accumbens (with 3,4-dihydroxyphenylamino-2-imidazoline hydrochloride; DPI and ergometrine) was investigated. In the nucleus accumbens, the modulatory effects of ergometrine and DPI on ACTH-(1-24)-induced grooming were based on their affinity for dopamine receptors and not on their affinity for adrenoceptors. Intrastriatal application of dopaminergic agents inhibited i.c.v. ACTH-(1-24)-induced excessive grooming, whereas the grooming score was enhanced if ACTH-(1-24) was administered into the substantia nigra. The finding of differential effects of dopaminergic agents on ACTH-induced excessive grooming depending on the route of administration indicate that i.c.v. ACTH-induced excessive grooming is not mediated solely through the substantia nigra. The increase in grooming behavior seen after the intrastriatal administration of dopaminergic agents - when ACTH was injected into the substantia nigra - suggests the involvement of the striato-nigral GABAergic pathway. Local injections of ACTH-(1-24) into the periaqueductal gray also induced excessive grooming. Since a second injection of ACTH-(1-24) into the periaqueductal gray did not lead to a grooming response, irrespective of where the first injection of ACTH-(1-24) was given (i.c.v. into the nigra or via the periaqueductal gray) it is suggested that this structure seems to play a primary role in the induction of excessive grooming. Therefore the modulatory effects of the dopaminergic influence on ACTH-(1-24)-induced grooming may be exerted via the striato-nigro-collicular pathway.
在将促肾上腺皮质激素（ACTH）-(1 - 24)注入黑质或脑室内（i.c.v.）后，对其诱导的梳理行为进行了研究。研究了新纹状体（用氟哌啶醇和阿扑吗啡）和伏隔核（用盐酸3,4 - 二羟基苯氨基 - 2 - 咪唑啉；DPI和麦角新碱）中多巴胺受体的调节情况。在伏隔核中，麦角新碱和DPI对ACTH-(1 - 24)诱导的梳理行为的调节作用基于它们对多巴胺受体的亲和力，而非对肾上腺素能受体的亲和力。纹状体内应用多巴胺能药物可抑制i.c.v. ACTH-(1 - 24)诱导的过度梳理行为，而如果将ACTH-(1 - 24)注入黑质，则梳理行为评分会升高。多巴胺能药物对ACTH诱导的过度梳理行为的影响因给药途径而异，这一发现表明i.c.v. ACTH诱导的过度梳理行为并非仅通过黑质介导。当将ACTH注入黑质时，纹状体内注射多巴胺能药物后出现的梳理行为增加表明纹状体 - 黑质γ-氨基丁酸能通路参与其中。向导水管周围灰质局部注射ACTH-(1 - 24)也会诱导过度梳理行为。由于无论首次注射ACTH-(1 - 24)是在何处进行（i.c.v.注入黑质或通过导水管周围灰质），第二次向导水管周围灰质注射ACTH-(1 - 24)都不会引发梳理反应，因此提示该结构似乎在过度梳理行为的诱导中起主要作用。所以多巴胺能影响对ACTH-(1 - 24)诱导的梳理行为的调节作用可能是通过纹状体 - 黑质 - 顶盖通路发挥的。
