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Activated murine alpha-globin gene is not preferentially associated with the nuclear matrix.

作者信息

Kirov N, Tsanev R

出版信息

Int J Biochem. 1986;18(2):155-9. doi: 10.1016/0020-711x(86)90148-5.

DOI:10.1016/0020-711x(86)90148-5
PMID:3005069
Abstract

The association of the murine alpha-globin gene with the nuclear matrix was studied in three different states of the gene: inactive (EAT cells), potentially active (MEL cells) and active (induced MEL cells). When "native" nuclei were digested with DNase I it was found that the nuclear matrix was not enriched in alpha-globin DNA sequences in all three different types of cells. A nuclease-hypersensitive site in the 5'-flanking region of the alpha-globin gene was detected in the induced MEL-cells.

摘要

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Preferential association of a transcriptionally active gene with the nuclear matrix of rat fibroblasts transformed by a simian-virus-40-pBR322 recombinant plasmid.
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