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对采用减积术和冷冻疗法治疗的犬眼睑肿物的回顾性评估:46例病例。

Retrospective evaluation of canine palpebral masses treated with debulking and cryotherapy: 46 cases.

作者信息

Zibura Ashley E, Henriksen Michala de Linde, Rendahl Aaron, Lim Christine C, Reilly Christopher

机构信息

Comparative Ophthalmology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.

Comparative Ophthalmology, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.

出版信息

Vet Ophthalmol. 2019 May;22(3):256-264. doi: 10.1111/vop.12585. Epub 2018 Jul 27.

DOI:10.1111/vop.12585
PMID:30052302
Abstract

PURPOSE

To evaluate the recurrence frequency and the time to recurrence of canine palpebral masses treated with debulking and cryotherapy.

METHODS

Medical records of dogs that underwent debulking and cryotherapy for palpebral masses from December 2010 to November 2015 at the University of Minnesota's Veterinary Medical Center were reviewed. A telephone survey with owners was used to determine recurrence and time to recurrence.

RESULTS

Forty-six masses (31 dogs) were included in this retrospective study. Included palpebral masses were as follows: adenomas 17/46 (37%), epitheliomas 8/46 (17.4%), papillomas 6/46 (13%), inflammatory masses 6/46 (13%), mixed adenoma-papillomas 6/46 (13%), mixed epithelioma-papillomas 2/46 (4.4%), and a melanocytoma 1/46 (2.2%). Of the seven masses that were noted to recur (7/46, 15.2%), three were mixed adenoma-papillomas (three of six adenoma-papillomas, 50%), two were epitheliomas (two of eight epitheliomas, 25%), one was a papilloma (one of six papillomas, 16.7%), and one was a melanocytoma (one of one melanocytoma, 100%). Average recurrence time was 367.9 days [range: 30-904 days]. A significant association between tumor type and tumor recurrence was found (P = .009). Adenomas were significantly less likely to recur (P = .017), and mixed adenoma-papillomas were significantly more likely to recur (P = .001).

CONCLUSIONS

Debulking and cryotherapy is an effective method of treatment for eyelid masses in dogs with a low study recurrence rate of 15.2% and average recurrence time of 367.9 days. Results also suggest that mixed adenoma-papilloma masses have a significantly higher recurrence rate than other eyelid masses, whereas adenomas had no recurrence in our study population.

摘要

目的

评估减瘤术联合冷冻疗法治疗犬睑肿物的复发频率及复发时间。

方法

回顾2010年12月至2015年11月在明尼苏达大学兽医学院接受睑肿物减瘤术联合冷冻疗法治疗的犬的病历。通过与犬主进行电话调查来确定复发情况及复发时间。

结果

本回顾性研究纳入了46个肿物(31只犬)。纳入的睑肿物如下:腺瘤17/46(37%)、上皮瘤8/46(17.4%)、乳头状瘤6/46(13%)、炎性肿物6/46(13%)、混合性腺瘤-乳头状瘤6/46(13%)、混合性上皮瘤-乳头状瘤2/46(4.4%)以及1个黑素细胞瘤1/46(2.2%)。在记录到复发的7个肿物中(7/46,15.2%),3个是混合性腺瘤-乳头状瘤(6个混合性腺瘤-乳头状瘤中的3个,50%),2个是上皮瘤(8个上皮瘤中的2个,25%),1个是乳头状瘤(6个乳头状瘤中的1个,16.7%),1个是黑素细胞瘤(1个黑素细胞瘤中的1个,100%)。平均复发时间为367.9天[范围:30 - 904天]。发现肿瘤类型与肿瘤复发之间存在显著关联(P = 0.009)。腺瘤复发的可能性显著较低(P = 0.017),而混合性腺瘤-乳头状瘤复发的可能性显著较高(P = 0.001)。

结论

减瘤术联合冷冻疗法是治疗犬眼睑肿物的有效方法,本研究中复发率低,为15.2%,平均复发时间为367.9天。结果还表明,混合性腺瘤-乳头状瘤肿物的复发率显著高于其他眼睑肿物,而在我们的研究群体中腺瘤未出现复发。

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