G 蛋白偶联受体在 NLRP3 炎性小体激活、调控和治疗中的作用。
GPCRs in NLRP3 Inflammasome Activation, Regulation, and Therapeutics.
机构信息
Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China; Laboratory of Nutrition, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China; These authors contributed equally to this work.
Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China; Department of Immunology, Anhui Provincial Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui 233030, China; These authors contributed equally to this work.
出版信息
Trends Pharmacol Sci. 2018 Sep;39(9):798-811. doi: 10.1016/j.tips.2018.07.002. Epub 2018 Jul 24.
The NLRP3 inflammasome is an intracellular multimeric protein complex which plays an important role in the pathogenesis of various human inflammatory diseases, such as diabetes, Alzheimer's disease and atherosclerosis. Recently, various G protein-coupled receptors (GPCRs) have been reported to be involved in the activation and regulation of the NLRP3 inflammasome by sensing multiple ions, metabolites, and neurotransmitters, suggesting GPCR signaling is an important regulator for NLRP3 inflammasome. Here, we will review how various GPCRs promote or inhibit NLRP3 inflammasome activation and discuss the implications of GPCRs as drug targets for the therapy of NLRP3-driven diseases.
NLRP3 炎性小体是一种细胞内多聚体蛋白复合物，在多种人类炎症性疾病的发病机制中发挥着重要作用，如糖尿病、阿尔茨海默病和动脉粥样硬化。最近，各种 G 蛋白偶联受体（GPCRs）被报道通过感应多种离子、代谢物和神经递质参与 NLRP3 炎性小体的激活和调节，这表明 GPCR 信号是 NLRP3 炎性小体的重要调节剂。在这里，我们将回顾各种 GPCR 如何促进或抑制 NLRP3 炎性小体的激活，并讨论 GPCR 作为 NLRP3 驱动疾病治疗的药物靶点的意义。
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