Karen was appointed Commander of the Order of the British Empire (CBE) in 2010 and Foreign Associate of the US National Academy of Sciences in May 2018. She is group leader at the Francis Crick Institute in London and Chief Scientist at Cancer Research UK. She is also a Fellow of the Royal Society (2004)
Dis Model Mech. 2018 Jul 27;11(8):dmm035675. doi: 10.1242/dmm.035675.
Karen Vousden is an internationally renowned cancer scientist whose contributions to solving the p53 puzzle are changing the way we think about this important tumour suppressor. She has been honoured with many prizes and elected memberships throughout her career, and was appointed Commander of the Order of the British Empire (CBE) in 2010 and Foreign Associate of the US National Academy of Sciences in May 2018. Karen is an approachable and diligent scientist, a respected mentor and an inspirational role model. She is currently a group leader at the Francis Crick Institute in London and Chief Scientist at Cancer Research UK (CRUK). In this interview, Karen talks about the mentors that inspired her, the discoveries that brought about her interest in cancer metabolism, and her interests outside the lab.Karen Vousden's research focuses on the many functions of p53 in cancer and beyond. Her scientific journey in the field of genetics started with undergraduate and graduate work on transfer RNA (tRNA) suppression with Lorna Casselton at the University of London, UK. She studied Ras and viral oncogenes during her postdoctoral training with Christopher Marshall and Douglas Lowy. The interactions between viral oncogenes and mammalian tumour suppressors drew her into the field of p53. Her group (in parallel with others) discovered the p53 targets and , the latter of which spurred her interest in cancer metabolism.
凯伦·沃斯登（Karen Vousden）是一位国际知名的癌症科学家，她在解决 p53 难题方面的贡献正在改变我们对这种重要肿瘤抑制因子的看法。在她的职业生涯中，她获得了许多奖项和当选为成员，并于 2010 年被任命为大英帝国司令勋章（CBE）获得者，2018 年 5 月被选为美国国家科学院外籍院士。凯伦是一位平易近人和勤奋的科学家，一位受人尊敬的导师和鼓舞人心的榜样。她目前是伦敦弗朗西斯·克里克研究所的一个小组组长和英国癌症研究中心（CRUK）的首席科学家。在这次采访中，凯伦谈到了激励她的导师、激发她对癌症代谢研究兴趣的发现，以及她实验室之外的兴趣。凯伦·沃斯登的研究重点是 p53 在癌症及其他领域的多种功能。她在遗传学领域的科研之旅始于英国伦敦大学与洛娜·卡塞尔顿（Lorna Casselton）合作的 tRNA 抑制方面的本科和研究生工作。她在与克里斯托弗·马歇尔（Christopher Marshall）和道格拉斯·洛（Douglas Lowy）的博士后培训中研究了 Ras 和病毒癌基因。病毒癌基因与哺乳动物肿瘤抑制因子的相互作用使她进入了 p53 领域。她的小组（与其他小组同时）发现了 p53 靶基因和，后者激发了她对癌症代谢的兴趣。
