用于为重复的ChIP-seq实验生成峰值调用的Sierra白金服务。
The Sierra Platinum Service for generating peak-calls for replicated ChIP-seq experiments.
作者信息
Wiegreffe Daniel, Müller Lydia, Steuck Jens, Zeckzer Dirk, Stadler Peter F
机构信息
Image and Signal Processing Group, Department of Computer Science, University of Leipzig, Augustusplatz 10, 04109, Leipzig, Germany.
Natural Language Processing Department, Department of Computer Science, University of Leipzig, Augustusplatz 10, 04109, Leipzig, Germany.
出版信息
BMC Res Notes. 2018 Jul 28;11(1):512. doi: 10.1186/s13104-018-3633-x.
OBJECTIVE
Sierra Platinum is a fast and robust peak-caller for replicated ChIP-seq experiments with visual quality-control and -steering. The required computing resources are optimized but still may exceed the resources available to researchers at biological research institutes.
RESULTS
Sierra Platinum Service provides the full functionality of Sierra Platinum: using a web interface, a new instance of the service can be generated. Then experimental data is uploaded and the computation of the peaks is started. Upon completion, the results can be inspected interactively and then downloaded for further analysis, at which point the service terminates.
目的
Sierra Platinum是一款用于重复ChIP-seq实验的快速且强大的峰识别工具，具有可视化质量控制和引导功能。所需的计算资源已得到优化，但仍可能超出生物研究机构研究人员可用的资源。
结果
Sierra Platinum服务提供了Sierra Platinum的全部功能：通过网络界面，可以生成该服务的新实例。然后上传实验数据并开始峰的计算。完成后，可以交互式检查结果，然后下载以供进一步分析，至此服务终止。
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