Miyamoto Hiroshi, Tanaka Kumiko, Nakamura Fumika, Ikeda Takahiro, Kitamura Shinji, Kimura Tetsuo, Okamoto Koichi, Sogabe Masahiro, Muguruma Naoki, Bando Yoshimi, Takayama Tetsuji
Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, Tokushima, 770-8503, Japan.
Department of Pathology, Tokushima University Hospital, Tokushima, Japan.
Clin J Gastroenterol. 2019 Feb;12(1):46-51. doi: 10.1007/s12328-018-0888-7. Epub 2018 Jul 28.
Hemobilia is defined as bleeding into the biliary tract. Herein, we report a very rare case of massive hemobilia following plastic stent (PS) removal in common bile duct (CBD) cancer. A 72-year-old man with primary sclerosing cholangitis had undergone repeated insertion of a PS into the CBD. Biliary tract biopsy was performed based on suspicion of combined CBD cancer. Biopsy revealed poorly differentiated adenocarcinoma of the CBD. One month after the biliary tract biopsy, he was admitted for acute cholangitis, and endoscopic retrograde cholangiography was performed for the exchange of the PS. When one of the two biliary PSs was removed, spurting bleeding from the major papilla began abruptly. The massive bleeding caused the patient to be in a pre-shock state. A retrieval balloon catheter was compressed against the papilla for hemostasis. Although he was treated conservatively, the patient developed a bloody discharge. Upper gastrointestinal endoscopy revealed that the pulsatile bleeding beside the PSs started immediately after the removal of the coagula. Emergent contrast-enhanced computed tomography showed right hepatic artery aneurysm across the CBD. Therefore, transarterial embolization was performed. The patient's post-therapeutic course was uneventful. He received chemotherapy, but died about a half year after hemobilia occurred.
胆道出血定义为血液进入胆道系统。在此,我们报告一例胆总管癌患者在取出塑料支架后发生大量胆道出血的极为罕见的病例。一名72岁患有原发性硬化性胆管炎的男性曾多次在胆总管内插入塑料支架。基于对合并胆总管癌的怀疑进行了胆道活检。活检显示为胆总管低分化腺癌。在胆道活检后一个月,他因急性胆管炎入院,并进行了内镜逆行胆管造影以更换塑料支架。当两个胆道塑料支架中的一个被取出时,主乳头突然开始喷射出血。大量出血导致患者处于休克前期状态。使用回收球囊导管压迫乳头进行止血。尽管对他进行了保守治疗,但患者仍出现血性分泌物。上消化道内镜检查显示,在取出凝血块后,塑料支架旁立即出现搏动性出血。急诊增强计算机断层扫描显示横跨胆总管的右肝动脉动脉瘤。因此,进行了经动脉栓塞术。患者的治疗后病程平稳。他接受了化疗,但在胆道出血发生约半年后死亡。