Won J G, Jap T S, Chang S C, Ching K N, Chiang B N
Metabolism. 1986 Mar;35(3):254-9. doi: 10.1016/0026-0495(86)90210-6.
To investigate the mechanisms responsible for glucocorticoid feedback on nonstress-induced ACTH secretion in normal subjects, 24 volunteer subjects (14 males and 10 females, 21 to 43 years) were divided into six groups in a randomized fashion and studied. Each subject received a single midnight dose of 30 mg/kg per body weight of metyrapone and then cortisol was administered according to different protocols in the next morning to provide extreme variations of the input signal. It was found that no obvious inhibition in plasma ACTH levels was shown during the first 15 min despite the fact that cortisol was given at rather larger doses and short time intervals. However, a significant suppression in plasma ACTH levels began to manifest approximately 30 min after cortisol administration in each study group and it became apparent that the degree of inhibition of ACTH level at 75 min correlated with the plasma cortisol concentrations at the same moment (r = 0.97, P less than 0.01) as well as with the dosage of cortisol during this time, whatever administered (r = 0.99, P less than 0.01). In summary, our data provided evidence for a delayed, proportional, and integral phase of glucocorticoid feedback on nonstress-induced ACTH secretion in normal human volunteers.
为了研究正常受试者中糖皮质激素对非应激诱导的促肾上腺皮质激素（ACTH）分泌的反馈机制，将24名志愿者受试者（14名男性和10名女性，年龄21至43岁）随机分为六组并进行研究。每位受试者在午夜单次给予每公斤体重30mg的美替拉酮，然后在第二天早晨根据不同方案给予皮质醇，以提供输入信号的极端变化。结果发现，尽管在短时间间隔内给予了相当大剂量的皮质醇，但在最初15分钟内血浆ACTH水平未显示出明显抑制。然而，在每个研究组中，皮质醇给药后约30分钟血浆ACTH水平开始出现显著抑制，并且明显的是，75分钟时ACTH水平的抑制程度与同一时刻的血浆皮质醇浓度相关（r = 0.97，P < 0.01），也与这段时间内皮质醇的剂量相关，无论如何给药（r = 0.99，P < 0.01）。总之，我们的数据为正常人类志愿者中糖皮质激素对非应激诱导的ACTH分泌的延迟、成比例和积分阶段的反馈提供了证据。
