Tremolada Marta, Bonichini Sabrina, Taverna Livia, Basso Giuseppe, Pillon Marta
Department of Developmental and Social Psychology, University of Padua, Padua, Italy.
Faculty of Education, Free University of Bozen-Bolzano, Brixen-Bressanone, Italy.
Eur J Cancer Care (Engl). 2018 Nov;27(6):e12878. doi: 10.1111/ecc.12878. Epub 2018 Jul 31.
This study was aimed at comparing adolescent and young adult (AYA) Hematopoietic Stem Cell Transplantation (HSCT) paediatric cancer survivors and a control group of healthy peers in terms of Health-Related Quality of Life (HRQOL) and frequency of posttraumatic stress symptoms (PTSS). The participants were 32 AYA HSCT survivors and 28 matched healthy peers. The survivors were, on average, 19.4 years old (SD = 3.8), with an average age of 8.1 years (SD = 4.3) at diagnosis, and with a mean time, since treatment was completed, of 8.5 years (SD = 3.2). The majority of survivors (78.1%) did not show clinical PTSS, with intrusion symptoms most frequently reported in those who had undergone autologous HSCT (F = 3.3; df = 2; p = 0.05) and relapse presence in their treatment associated with more PTSS avoidance symptoms (r = 0.4; p = 0.002). Women reported more problems in the SF-36 pain scale (t = 2.1; df = 31; p = 0.04) than men. Additionally, 87.5% of survivors fell below the 25th percentile in the SF-36 general well-being scale, and 70.8% had the same trend for the SF-36 fatigue scale. Survivors reported better emotional well-being (t = 2.6, df = 27, p = 0.01) and fewer limitations than their healthy peers (t = 2.5, df = 27, p = 0.02), while they perceived a lower life satisfaction referring to the past (t = -2.8, df = 27, p = 0.009).
本研究旨在比较青少年和青年（AYA）造血干细胞移植（HSCT）的儿科癌症幸存者与健康同龄对照组在健康相关生活质量（HRQOL）和创伤后应激症状（PTSS）频率方面的差异。参与者包括32名AYA HSCT幸存者和28名匹配的健康同龄人。幸存者平均年龄为19.4岁（标准差=3.8），诊断时平均年龄为8.1岁（标准差=4.3），自治疗结束后的平均时间为8.5年（标准差=3.2）。大多数幸存者（78.1%）未表现出临床PTSS，自体HSCT患者中侵入性症状报告最为频繁（F=3.3；自由度=2；p=0.05），治疗中出现复发与更多的PTSS回避症状相关（r=0.4；p=0.002）。女性在SF-36疼痛量表上报告的问题比男性更多（t=2.1；自由度=31；p=0.04）。此外，87.5%的幸存者在SF-36总体幸福感量表上低于第25百分位数，70.8%的幸存者在SF-36疲劳量表上也有同样的趋势。与健康同龄人相比，幸存者报告的情绪幸福感更好（t=2.6，自由度=27，p=0.01），限制更少（t=2.5，自由度=27，p=0.02），而他们对过去生活满意度的感知较低（t=-2.8，自由度=27，p=0.009）。
