Fyfe N C, Price E W
Trans R Soc Trop Med Hyg. 1985;79(5):645-51. doi: 10.1016/0035-9203(85)90180-4.
Non-filarial tropical elephantiasis, which occurs in certain volcanic areas of the world, has been postulated to be an obstructive lymphopathy due to the fibrogenic effects of silica absorbed through the plantar skin of bare-footed people. Animal experiments involving the direct intralymphatic injection of fine silica particles have been carried out in order to assess the extent to which this substance can engender lymphatic obstruction and to determine its main site of action. Intralymphatic silica provoked an immediate and intense macrophage reaction with later fibrosis both within lymph vessels and to a lesser extent within lymph nodes. Lymphography indicated that the consequent obstruction resulted more from the effects of silica on vessels than on nodes.
非丝虫性热带象皮病发生在世界上某些火山地区，据推测是一种阻塞性淋巴病，起因是赤脚者足底皮肤吸收二氧化硅产生的致纤维化作用。为了评估这种物质引发淋巴阻塞的程度并确定其主要作用部位，已开展了直接向淋巴管内注射细二氧化硅颗粒的动物实验。淋巴管内注射二氧化硅引发了即时且强烈的巨噬细胞反应，随后在淋巴管内以及程度较轻地在淋巴结内出现纤维化。淋巴造影显示，由此导致的阻塞更多是二氧化硅对血管而非对淋巴结产生作用的结果。
