慢性阻塞性肺疾病患者的蛋白尿：在非洲患者队列中的一项横断面研究。
Albuminuria in patients with chronic obstructive pulmonary disease: a cross-sectional study in an African patient cohort.
机构信息
Department of Internal Medicine, Muhimbili University of Health and Allied Sciences, P.O BOX 65001, Dar es Salaam, Tanzania.
Department of Internal Medicine, Muhimbili National Hospital, P.o box 14087, Dar es Salaam, Tanzania.
出版信息
BMC Pulm Med. 2018 Jul 31;18(1):125. doi: 10.1186/s12890-018-0694-5.
BACKGROUND
Cardiovascular disease (CVD) is remarkably frequent in patients with chronic obstructive pulmonary disease (COPD). Albuminuria is a marker of vascular endothelial dysfunction and predictor of CVD events. Albuminuria is prevalent in patients with COPD as it has been shown in Caucasian and Oriental populations with COPD. The objective of this study was to determine the prevalence of Albuminuria and COPD severity correlates among black patients with chronic obstructive pulmonary disease in order to see whether a similar trend of albuminuria is also prevalent in this population.
METHODS
A total of 104 COPD patients were enrolled in the study. Lung functions were assessed by means of the Easy One™ spirometer. Albuminuria defined by urine albumin to creatinine ratio (ACR) was tested using CYBOW 12MAC microalbumin strips in a random spot urine collection. SPSS version 20 was used for data analysis.
RESULTS
In the studied population, 25/104 (24%) patients had albuminuria and 16/104 (15.4%) patients had CVD. Abnormal urine albumin (Albuminuria and Proteinuria) was present in all patients with CVD. In the subset of 46 COPD patients assessed for severity, 60.9% (95%CIs 46.1-73.9) had moderate COPD and 30.4% (95% CIs, 17.9-49.0) severe COPD. Albuminuria was moderately significantly associated with COPD severity, p = 0.049; (0.049 < p < 0.05). Participants who ever smoked cigarettes had significantly likelihood of severe and very severe COPD (OR 11.5; 95% CIs, 1.3, 98.4) however, the significance was lost when adjusted for age and gender.
CONCLUSION
Albuminuria was prevalent in patients with COPD and it had a significant association with COPD severity.
背景
心血管疾病（CVD）在慢性阻塞性肺疾病（COPD）患者中非常常见。白蛋白尿是血管内皮功能障碍的标志物，也是 CVD 事件的预测因子。白蛋白尿在 COPD 患者中很常见，因为在白种人和东方 COPD 人群中已经有了这样的发现。本研究的目的是确定黑种人 COPD 患者中白蛋白尿的流行率和 COPD 严重程度的相关性，以了解这种白蛋白尿的趋势是否也在这一人群中普遍存在。
方法
共有 104 例 COPD 患者入组本研究。通过 Easy One™ 肺量计评估肺功能。使用 CYBOW 12MAC 微量白蛋白条在随机尿样中检测尿白蛋白与肌酐比值（ACR）来定义白蛋白尿。使用 SPSS 版本 20 进行数据分析。
结果
在所研究的人群中，25/104（24%）患者有白蛋白尿，16/104（15.4%）患者有 CVD。所有 CVD 患者均有异常尿白蛋白（白蛋白尿和蛋白尿）。在评估严重程度的 46 例 COPD 患者亚组中，60.9%（95%CI，46.1-73.9）患者为中度 COPD，30.4%（95%CI，17.9-49.0）为重度 COPD。白蛋白尿与 COPD 严重程度中度显著相关，p=0.049；（0.049<p<0.05）。曾吸烟的患者患重度和极重度 COPD 的可能性显著增加（OR 11.5；95%CI，1.3，98.4），然而，当调整年龄和性别后，这种显著意义就丧失了。
结论
白蛋白尿在 COPD 患者中很常见，与 COPD 严重程度有显著相关性。
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