Yahav J, Lee P C, Lebenthal E
Am J Physiol. 1986 Feb;250(2 Pt 1):G200-4. doi: 10.1152/ajpgi.1986.250.2.G200.
By use of isolated gastric glands from rats at various ages, we demonstrated that full-term neonate and 1-day-old rats showed no response to cholecystokinin octapeptide (CCK-OP), carbachol, or Ca2+ ionophore. The same glands, however, were responsive to dibutyryl cAMP. A mature response was not found until the pups were 2 days old. Injection of hydrocortisone into newborn rats led to an increase in pepsinogen concentrations in gastric glands and also an increased responsiveness to CCK-OP, carbachol, and Ca2+ ionophore A23187 24 h after administration. Hydrocortisone thus caused precocious maturation of both pepsinogen accumulation and pepsinogen secretory responsiveness of gastric glands in rat pups.
通过使用来自不同年龄大鼠的分离胃腺，我们证明足月新生儿和1日龄大鼠对八肽胆囊收缩素（CCK-OP）、卡巴胆碱或Ca2+离子载体无反应。然而，相同的腺体对二丁酰环磷酸腺苷（dibutyryl cAMP）有反应。直到幼崽2日龄时才发现成熟反应。给新生大鼠注射氢化可的松导致给药后24小时胃腺中胃蛋白酶原浓度增加，并且对CCK-OP、卡巴胆碱和Ca2+离子载体A23187的反应性也增加。因此，氢化可的松导致幼鼠胃腺中胃蛋白酶原积累和胃蛋白酶原分泌反应性的早熟成熟。
