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Differential Effects of Digoxin on Imiquimod-Induced Psoriasis-Like Skin Inflammation on the Ear and Back.

作者信息

Madsen Marie, Pedersen Tanja Xenia, Nielsen Lars Bo, Johansen Claus, Hansen Peter Riis

机构信息

Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

出版信息

Ann Dermatol. 2018 Aug;30(4):485-488. doi: 10.5021/ad.2018.30.4.485. Epub 2018 Jun 28.

DOI:10.5021/ad.2018.30.4.485
PMID:30065596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6029971/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9873/6029971/31aef1f16e38/ad-30-485-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9873/6029971/31aef1f16e38/ad-30-485-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9873/6029971/31aef1f16e38/ad-30-485-g001.jpg

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Ann Dermatol. 2018 Aug;30(4):485-488. doi: 10.5021/ad.2018.30.4.485. Epub 2018 Jun 28.
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Imiquimod-Induced Psoriasis-Like Skin Lesions Do Not Accelerate Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice.咪喹莫特诱导的银屑病样皮肤损伤不会加速低密度脂蛋白受体缺陷型小鼠的动脉粥样硬化。
Am J Pathol. 2018 Jun;188(6):1486-1496. doi: 10.1016/j.ajpath.2018.02.005. Epub 2018 Mar 12.
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MAD ointment ameliorates Imiquimod-induced psoriasiform dermatitis by inhibiting the IL-23/IL-17 axis in mice.MAD软膏通过抑制小鼠体内的IL-23/IL-17轴来改善咪喹莫特诱导的银屑病样皮炎。
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Imiquimod-induced psoriasis-like skin inflammation is suppressed by BET bromodomain inhibitor in mice through RORC/IL-17A pathway modulation.咪喹莫特诱导的银屑病样皮肤炎症在小鼠中通过RORC/IL-17A途径调节被BET溴结构域抑制剂抑制。
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World J Gastroenterol. 2023 Mar 28;29(12):1824-1837. doi: 10.3748/wjg.v29.i12.1824.
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本文引用的文献

1
Digoxin reduces atherosclerosis in apolipoprotein E-deficient mice.地高辛可减轻载脂蛋白E缺乏小鼠的动脉粥样硬化。
Br J Pharmacol. 2016 May;173(9):1517-28. doi: 10.1111/bph.13453. Epub 2016 Mar 11.
2
Topical imiquimod yields systemic effects due to unintended oral uptake.由于意外的口服摄入，局部应用咪喹莫特会产生全身效应。
Sci Rep. 2016 Jan 28;6:20134. doi: 10.1038/srep20134.
3
Small molecule mediated inhibition of RORγ-dependent gene expression and autoimmune disease pathology in vivo.小分子在体内介导对RORγ依赖性基因表达及自身免疫病病理的抑制作用。
胞质RNA传感器作为银屑病发病机制中角质形成细胞分化抑制剂的潜在作用。
Ann Dermatol. 2021 Aug;33(4):339-344. doi: 10.5021/ad.2021.33.4.339. Epub 2021 Jul 1.
4
Possible Role of Lysine Demethylase 2A in the Pathophysiology of Psoriasis.赖氨酸去甲基化酶2A在银屑病病理生理学中的可能作用。
Ann Dermatol. 2020 Dec;32(6):481-486. doi: 10.5021/ad.2020.32.6.481. Epub 2020 Nov 11.
5
Application of imiquimod-induced murine psoriasis model in evaluating interleukin-17A antagonist.咪喹莫特诱导的银屑病小鼠模型在评价白细胞介素-17A 拮抗剂中的应用。
BMC Immunol. 2021 Jan 28;22(1):11. doi: 10.1186/s12865-021-00401-3.
6
Barrier lipid composition and response to plasma lipids: A direct comparison of mouse dorsal back and ear skin.屏障脂质组成与对血浆脂质的反应：小鼠背部和耳部皮肤的直接比较。
Exp Dermatol. 2020 Jun;29(6):548-555. doi: 10.1111/exd.14106. Epub 2020 May 21.
Immunology. 2016 Apr;147(4):399-413. doi: 10.1111/imm.12570. Epub 2016 Jan 26.
4
Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo.药物抑制 RORγt 可调控 Th17 特征基因的表达并在体内抑制皮肤炎症。
J Immunol. 2014 Mar 15;192(6):2564-75. doi: 10.4049/jimmunol.1302190. Epub 2014 Feb 10.
5
Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis.鞘氨醇-1-磷酸在银屑病小鼠模型中表现出抗增殖和抗炎作用。
J Dermatol Sci. 2013 Jul;71(1):29-36. doi: 10.1016/j.jdermsci.2013.03.006. Epub 2013 Apr 6.
6
The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings.IL-17 在银屑病发病机制中的新作用：临床前和临床研究发现。
J Invest Dermatol. 2013 Jan;133(1):17-26. doi: 10.1038/jid.2012.194. Epub 2012 Jun 7.
7
Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice.Rorγt+ 先天淋巴细胞和 γδ T 细胞启动小鼠银屑病样斑块形成。
J Clin Invest. 2012 Jun;122(6):2252-6. doi: 10.1172/JCI61862. Epub 2012 May 1.
8
Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity.地高辛及其衍生物通过拮抗 RORγt 活性来抑制 TH17 细胞分化。
Nature. 2011 Apr 28;472(7344):486-90. doi: 10.1038/nature09978. Epub 2011 Mar 27.
9
Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis.咪喹莫特诱导的小鼠银屑病样皮肤炎症是通过白细胞介素-23/白细胞介素-17轴介导的。
J Immunol. 2009 May 1;182(9):5836-45. doi: 10.4049/jimmunol.0802999.
10
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.孤儿核受体RORγt指导促炎性白细胞介素-17+辅助性T细胞的分化程序。
Cell. 2006 Sep 22;126(6):1121-33. doi: 10.1016/j.cell.2006.07.035.