Mikou P, Lenos M, Papaioannou D, Vrettou K, Trigka E-A, Sousouris S, Constantinides C
Department of Cytopathology, Laiko Hospital, Athens, Greece.
Department of Histopathology, Diagnostic and Therapeutic Centre of Athens - Hygeia, Athens, Greece.
Cytopathology. 2018 Dec;29(6):545-549. doi: 10.1111/cyt.12585. Epub 2018 Aug 1.
Our aim was to evaluate the Paris System for reporting urinary cytology, especially in the field of atypia.
During the last year, 104 urinary cases had atypical cytology. These cases were reviewed and reclassified by three cytopathologists using the Paris criteria. Cyto-histological correlation was performed in 47 cases. Additionally, all cytology diagnoses were correlated with double immunocytochemistry for p53 and CK20 result. Interobserver consistency was also evaluated.
Out of 104 atypical cases, 30 were classified as benign, 49 atypical and 25 suspicious for high-grade urothelial carcinoma (HGUC). Diagnostic consistency between the three observers reached 93.27%. Using the new criteria, only 47.1% of the cases remained in the atypical category. The rate of HGUC histology was 14.3%, 26.7% and 96% in the benign, atypical and suspicious for HGUC cytological categories, respectively. Immunocytochemistry positivity was observed in 25.9%, 41.8% and 80% of the cases in the three diagnostic groups.
The Paris System for reporting urinary cytology provides clear, easy to adopt criteria, which lead to diagnostic categories with clinical significance, facilitating patient management decisions.
我们的目的是评估用于报告尿细胞学检查结果的巴黎系统，尤其是在非典型性方面。
在过去一年中，104例尿细胞学检查结果为非典型性。这3位细胞病理学家使用巴黎标准对这些病例进行了复查和重新分类。对47例病例进行了细胞组织学相关性分析。此外，将所有细胞学诊断结果与p53和细胞角蛋白20的双重免疫细胞化学结果进行了相关性分析。还评估了观察者间的一致性。
在104例非典型病例中，30例被分类为良性，49例为非典型性，25例疑似高级别尿路上皮癌（HGUC）。三位观察者之间的诊断一致性达到93.27%。采用新标准后，只有47.1%的病例仍属于非典型类别。在良性、非典型性和疑似HGUC细胞学类别的病例中，HGUC组织学的发生率分别为14.3%、26.7%和96%。在三个诊断组中，分别有25.9%、41.8%和80%的病例观察到免疫细胞化学阳性。
用于报告尿细胞学检查结果的巴黎系统提供了清晰、易于采用的标准，这些标准可得出具有临床意义的诊断类别，有助于做出患者管理决策。
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