Malone M, Lumley H, Erdohazi M
Cancer. 1986 May 15;57(10):1979-85. doi: 10.1002/1097-0142(19860515)57:10<1979::aid-cncr2820571016>3.0.co;2-r.
Three cases of astrocytoma, two cerebral (grades II and III) and one spinal (grade II) occurring as second malignancies in patients with previously diagnosed acute lymphoblastic leukemia are described. All had received prophylactic cranial irradiation and intrathecal methotrexate. All were in remission at the time of development of the second malignancy. The time interval between central nervous system (CNS) prophylaxis and symptoms of CNS tumor was between 3 and 5 years. The possible causes of the combination of astrocytoma with acute lymphoblastic leukemia are discussed.
本文描述了3例星形细胞瘤病例，其中2例为脑星形细胞瘤（Ⅱ级和Ⅲ级），1例为脊髓星形细胞瘤（Ⅱ级），这些病例均发生于先前诊断为急性淋巴细胞白血病的患者，为第二原发性恶性肿瘤。所有患者均接受了预防性颅脑照射和鞘内注射甲氨蝶呤。第二原发性恶性肿瘤发生时，所有患者均处于缓解期。中枢神经系统（CNS）预防措施与CNS肿瘤症状出现之间的时间间隔为3至5年。本文还讨论了星形细胞瘤与急性淋巴细胞白血病合并发生的可能原因。
