Salen-Ti(IV) 配合物的合成与表征及其在 D, L-丙交酯可控聚合中的应用。

Synthesis and characterization of salen-Ti(IV) complex and application in the controllable polymerization of D, L-lactide.

机构信息

School of Civil Engineering and Architecture, Chongqing University of Science and Technology, Chongqing, China.

Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment, State Ministry of Education, Chongqing University, Chongqing, China.

出版信息

PLoS One. 2018 Aug 2;13(8):e0201054. doi: 10.1371/journal.pone.0201054. eCollection 2018.

DOI:10.1371/journal.pone.0201054

PMID:30071033

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6071980/

Abstract

Poly(lactic acid) has been extensively investigated in the biomedical field because of its good biocompatibility and biodegradability. As an important method of poly(lactic acid) synthesis, metal complex-catalyzed ring-opening polymerization (ROP) of lactide can achieve a controllable lactide polymerization through the selection of appropriate ligands and metals. In this study, a novel metal (LTi-O)2 complex was synthesized and structurally characterized. (LTi-O)2 showed a relatively high catalytic activity and controllability of Poly(D, L-lactide) (PDLLA) molecular weights (polydispersity index of 1.02-1.22) in the ROP of D,L-lactide. The kinetic equation of D,L-LA ROP catalyzed by (LTi-O)2 could be expressed as-d[M]/dt = k[M]2[(LTi-O)2]1, and the reaction activation energy was 95.67 kJ·mol-1. Physical/chemical properties and biocompatibility evaluation results showed that PDLLA obtained through the (LTi-O)2-catalyzed ROP of D,L- lactide exhibited a good degradation performance and excellent biocompatibility.

摘要

聚乳酸因其良好的生物相容性和可生物降解性而在生物医学领域得到了广泛的研究。作为聚乳酸合成的一种重要方法，丙交酯的金属络合催化开环聚合（ROP）可以通过选择合适的配体和金属来实现对丙交酯聚合的可控性。在本研究中，合成并结构表征了一种新型金属（LTi-O）2络合物。（LTi-O）2在 D,L-丙交酯的 ROP 中表现出相对较高的催化活性和聚（D,L-丙交酸酯）（PDLLA）分子量的可控性（PDLLA 的多分散指数为 1.02-1.22）。（LTi-O）2催化的 D,L-LA ROP 的动力学方程可以表示为-d[M]/dt = k[M]2[(LTi-O)2]1，反应活化能为 95.67 kJ·mol-1。物理/化学性质和生物相容性评价结果表明，通过（LTi-O）2催化的 D,L-丙交酯 ROP 得到的 PDLLA 具有良好的降解性能和优异的生物相容性。