Kaya Cihan, Alay Ismail, Guraslan Hakan, Gedikbasi Asuman, Ekin Murat, Ertaş Kaya Sinem, Oral Engin, Yasar Levent
Department of Obstetrics and Gynecology, University of Health Sciences, Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul,
Department of Obstetrics and Gynecology, University of Health Sciences, Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
Gynecol Obstet Invest. 2018;83(6):576-585. doi: 10.1159/000489494. Epub 2018 Aug 2.
BACKGROUND/AIMS: To identify the role of serum caspase 3, Annexin A2 (ANXA2), and Soluble Fas Ligand (sFasL) levels in the prediction of endometriosis severity.
The study was performed on 90 women who were candidates for laparoscopic surgery due to endometrioma or any other benign ovarian cysts detected by ultrasound examination, pelvic pain, or infertility. The control group comprised 29 patients. The second group comprised 29 patients with stage I-II endometriosis and the third group comprised 30 patients with stage III-IV endometriosis.
Significant differences were detected between the control and stage III-IV endometriosis groups and between stage I-II and stage III-IV endometriosis groups in terms of caspase-3 levels (both, p < 0.001), ANXA2 levels (p = 0.007 and p = 0.002), and sFasL levels (p = 0.022 and p = 0.044). After receiver operating characteristic analysis, the area under curve was 93% (95% CI 57-82) at 10.7 ng/mL cut-off level for caspase-3 with 90% sensitivity and 87% specificity.
Serum caspase-3 level may be a reliable predictor of endometriosis severity.
背景/目的：确定血清半胱天冬酶3、膜联蛋白A2（ANXA2）和可溶性Fas配体（sFasL）水平在预测子宫内膜异位症严重程度中的作用。
该研究对90名因子宫内膜瘤或超声检查发现的任何其他良性卵巢囊肿、盆腔疼痛或不孕而准备接受腹腔镜手术的女性进行。对照组包括29名患者。第二组包括29名I-II期子宫内膜异位症患者，第三组包括30名III-IV期子宫内膜异位症患者。
在半胱天冬酶-3水平（均为p < 0.001）、ANXA2水平（p = 0.007和p = 0.002）和sFasL水平（p = 0.022和p = 0.044）方面，对照组与III-IV期子宫内膜异位症组之间以及I-II期与III-IV期子宫内膜异位症组之间均检测到显著差异。经受试者工作特征分析，半胱天冬酶-3在10.7 ng/mL临界值时曲线下面积为93%（95%CI 57-82），敏感性为90%，特异性为87%。
血清半胱天冬酶-3水平可能是子宫内膜异位症严重程度的可靠预测指标。
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