Zhou Xiaoming, Shen Weiwei, Zhu Jue, Chen Yichen, Zhang Jing
Department of Gynecology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, 315010, People's Republic of China.
Department of Gynecology, Ningbo Women & Children's Hospital, Ningbo, Zhejiang, 315010, People's Republic of China.
Int J Womens Health. 2024 Jul 30;16:1293-1301. doi: 10.2147/IJWH.S466189. eCollection 2024.
To investigate the association between the oxidative balance score (OBS) and endometriosis.
This cross-sectional study used four cycles of the National Health and Nutrition Examination Survey (NHANES) (1999-2000, 2001-2002, 2003-2004, and 2005-2006). OBS involved 16 dietary nutrients and 4 lifestyle factors, including 5 pro-oxidants and 15 anti-oxidants. According to weighted quartiles, the OBS was divided into four categories: < 12.54, 12.54-18.70, 18.71-24.68, and > 24.68. Endometriosis was diagnosed based on a question from the reproductive health questionnaire. Weighted multivariate logistic analysis was used to investigate the association between OBS and endometriosis. Subgroup analysis was performed based on menstrual regularity and female hormone use.
A total of 5095 women were included, with 1140 (22.37%), 1232 (24.18%), 1224 (24.02%), and 1499 (29.42%) women in the OBS < 12.54, of 12.54-18.70, of 18.71-24.68, and > 24.68 categories, respectively. After adjusting age, race, family poverty-to-income ratio (PIR), education level, uterine fibroids, menstrual regularity, oophorectomy, female hormone use, hypertension, dyslipidemia, and steroid drug, a high OBS (> 24.68) was found to be associated with lower odds of endometriosis [odds ratio (OR) = 0.70, 95% confidence interval (CI): 0.50-0.97, = 0.033] compared to a low OBS (< 12.54). The similar result was also found in women with irregular menstruation (OR = 0.58, 95% CI: 0.37-0.91, = 0.020) and with female hormone use (OR = 0.71, 95% CI: 0.52-0.98, = 0.037).
A high OBS was associated with lower odds of endometriosis, especially in women with irregular menstruation and female hormone use.
探讨氧化平衡评分（OBS）与子宫内膜异位症之间的关联。
这项横断面研究使用了美国国家健康与营养检查调查（NHANES）的四个周期（1999 - 2000年、2001 - 2002年、2003 - 2004年和2005 - 2006年）。OBS涉及16种膳食营养素和4种生活方式因素，包括5种促氧化剂和15种抗氧化剂。根据加权四分位数，OBS被分为四类：<12.54、12.54 - 18.70、18.71 - 24.68和>24.68。子宫内膜异位症根据生殖健康问卷中的一个问题进行诊断。采用加权多因素逻辑回归分析来研究OBS与子宫内膜异位症之间的关联。根据月经规律和女性激素使用情况进行亚组分析。
共纳入5095名女性，OBS<12.54、12.54 - 18.70、18.71 - 24.68和>24.68类别中的女性分别有1140名（22.37%）、1232名（24.18%）、1224名（24.02%）和1499名（29.42%）。在调整年龄、种族、家庭贫困收入比（PIR）、教育水平、子宫肌瘤、月经规律、卵巢切除术、女性激素使用、高血压、血脂异常和类固醇药物后，发现高OBS（>24.68）与子宫内膜异位症的较低发病几率相关[比值比（OR）=0.70，95%置信区间（CI）：0.50 - 0.97，P = 0.033]，与低OBS（<12.54）相比。在月经不规律的女性（OR = 0.58，95% CI：0.37 - 0.91，P = 0.020）和使用女性激素的女性（OR = 0.71，95% CI：0.52 - 0.98，P = 0.037）中也发现了类似结果。
高OBS与子宫内膜异位症的较低发病几率相关，尤其是在月经不规律和使用女性激素的女性中。
