Department of Food Nutrition and Health Biotechnology, Asia University, 500, Lioufeng Road, Wufeng, Taichung 41354, Taiwan.
Department of Medical Research, China Medical University Hospital, China Medical University, 2 Yude Road, Taichung 40447, Taiwan.
Mar Drugs. 2018 Aug 1;16(8):263. doi: 10.3390/md16080263.
To investigate a high cholesterol diet in Alzheimer's disease (AD) mice, they were fed with (2% cholesterol) in five groups with a control group, AD mice group, AD mice plus group, AD mice plus group, and, AD mice plus group for three months, and treated with the fatty acid profiles of clams by gas chromatography (GC). The results showed that treatment with clams for three months reduced Fas/L and Caspase-3 in the and groups, but Fas-associated death domain (FADD) and Caspase-8 were strongly reduced in the group. For the mitochondria-dependent apoptotic pathway, the reduction of apoptosis proteins were observed in the hearts of clams-treated AD mice. BAK and Caspase-9 was reduced in the group, but Caspase-3 and Cytochrome- were reduced in group. Enhancement of survival proteins p-AKT, p-IGF1R, p-PI3K, Bcl-XL, Bcl2, and the longevity SIRT1 signaling proteins, p-AMPK-α, SIRT1, PGC1-α, p-FOXO3 were observed in clams-treated mice and even more strongly enhanced in the , and groups. This study observed that the ingestion of clams caused a reduction of apoptosis proteins and enhancement of survival and SIRT1 signaling proteins in the hearts.
为了研究高胆固醇饮食对阿尔茨海默病（AD）小鼠的影响，将它们分为五组进行喂养，包括对照组、AD 小鼠组、AD 小鼠加组、AD 小鼠加组和 AD 小鼠加组，用气相色谱法（GC）分析贻贝的脂肪酸图谱。结果表明，贻贝治疗三个月可降低组和组的 Fas/L 和 Caspase-3，但组的 Fas 相关死亡结构域（FADD）和 Caspase-8 明显降低。对于线粒体依赖性凋亡途径，贻贝治疗的 AD 小鼠心脏中观察到凋亡蛋白减少。组中 BAK 和 Caspase-9 减少，但组中 Caspase-3 和 Cytochrome-减少。贻贝治疗组中观察到存活蛋白 p-AKT、p-IGF1R、p-PI3K、Bcl-XL、Bcl2 和长寿 SIRT1 信号蛋白 p-AMPK-α、SIRT1、PGC1-α、p-FOXO3 的增强，并且在组、组和组中增强更为明显。本研究观察到贻贝的摄入可减少心脏中的凋亡蛋白，并增强存活和 SIRT1 信号蛋白。
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