大脑胆固醇代谢中的微小RNA及其对阿尔茨海默病的影响。
MicroRNAs in brain cholesterol metabolism and their implications for Alzheimer's disease.
作者信息
Yoon Hyejin, Flores Luis F, Kim Jungsu
机构信息
Neurobiology of Disease Graduate Program, Mayo Graduate School, Jacksonville, FL, United States; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, United States.
Biochemistry and Molecular Biology Graduate Program, Mayo Graduate School, Jacksonville, FL, United States.
出版信息
Biochim Biophys Acta. 2016 Dec;1861(12 Pt B):2139-2147. doi: 10.1016/j.bbalip.2016.04.020. Epub 2016 May 4.
Cholesterol is important for various neuronal functions in the brain. Brain has elaborate regulatory mechanisms to control cholesterol metabolism that are distinct from the mechanisms in periphery. Interestingly, dysregulation of the cholesterol metabolism is strongly associated with a number of neurodegenerative diseases. MicroRNAs are short non-coding RNAs acting as post-transcriptional gene regulators. Recently, several microRNAs are demonstrated to be involved in regulating cholesterol metabolism in the brain. This article reviews the regulatory mechanisms of cellular cholesterol homeostasis in the brain. In addition, we discuss the role of microRNAs in brain cholesterol metabolism and their potential implications for the treatment of Alzheimer's disease. This article is part of a special issue entitled: MicroRNAs and lipid/energy metabolism and related diseases edited by Carlos Fernández-Hernando and Yajaira Suárez.
胆固醇对大脑中的各种神经元功能至关重要。大脑具有复杂的调节机制来控制胆固醇代谢，这些机制与外周的机制不同。有趣的是，胆固醇代谢失调与许多神经退行性疾病密切相关。微小RNA是短的非编码RNA，作为转录后基因调节因子发挥作用。最近，有几种微小RNA被证明参与调节大脑中的胆固醇代谢。本文综述了大脑中细胞胆固醇稳态的调节机制。此外，我们还讨论了微小RNA在大脑胆固醇代谢中的作用及其对阿尔茨海默病治疗的潜在意义。本文是由卡洛斯·费尔南德斯 - 埃尔南多和亚贾伊拉·苏亚雷斯编辑的名为《微小RNA与脂质/能量代谢及相关疾病》特刊的一部分。
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