Department of Neurology and Cancer Center, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Yawkey 9E, Boston, MA 02114, USA.
Department of Neurology and Cancer Center, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Yawkey 9E, Boston, MA 02114, USA.
Neurol Clin. 2018 Aug;36(3):501-516. doi: 10.1016/j.ncl.2018.04.007.
Meningiomas are the most common primary intracranial tumor in adults. With schwannomas, these tumors account for almost all intracranial benign tumors. Despite the benign histologic nature, patients suffer from neurologic symptoms and require treatment. Surgery remains the primary treatment for many such tumors, though radiation may be used either as a primary treatment or, commonly, for surgically inaccessible or recurrent lesions. The epidemiology, risk factors, and current data for local and systemic therapy options are reviewed. Active areas of research include exploration of the genetic landscape, identification of signaling pathway aberrations, and investigation of targeted systemic therapies.
脑膜瘤是成人中最常见的原发性颅内肿瘤。与神经鞘瘤一起，这些肿瘤几乎占所有颅内良性肿瘤。尽管组织学上是良性的，但患者会出现神经症状，需要治疗。手术仍然是许多此类肿瘤的主要治疗方法，尽管放射治疗既可以作为主要治疗方法，也可以用于治疗手术无法触及或复发的病变。本文综述了流行病学、危险因素以及局部和全身治疗选择的最新数据。目前的研究热点包括探索遗传特征、鉴定信号通路异常以及研究靶向全身治疗。
