Unidad de Anaplasmosis, Centro Nacional de Investigación Disciplinaria en Parasitología Veterinaria, (CENID-PAVET, INIFAP), Carretera Federal Cuernavaca Cuautla 8534, Progreso, 62574 Jiutepec, Morelos, Mexico.
Facultad de Ciencias, Departamento de Biología, Universidad Antonio Nariño, Sede Circunvalar Carrera 3 Este, No. 47 A15, Bogotá, Colombia.
Cytokine. 2018 Dec;112:63-74. doi: 10.1016/j.cyto.2018.07.024. Epub 2018 Jul 31.
Rickettsioses are zoonotic infections caused by obligate intracellular bacteria of the genera Rickettsia that affect human health; sometimes humans being considered as accidental hosts. At a molecular level, the rickettsiae infection triggers molecular signaling leading to the secretion of proinflammatory cytokines. These cytokines direct the immune response to the host cell damage and pathogen removal. In this review, we present metabolic aspects of the host cell in the presence of rickettsiae and how this presence triggers an inflammatory response to cope with the pathogen. We also reviewed the secretion of cytokines that modulates host cell response at immune and metabolic levels.
立克次体病是由立克次体属的专性细胞内细菌引起的人畜共患感染，影响人类健康；有时人类被认为是偶然宿主。在分子水平上，立克次体感染引发分子信号转导，导致促炎细胞因子的分泌。这些细胞因子指导免疫反应，以清除宿主细胞损伤和病原体。在这篇综述中，我们介绍了宿主细胞在立克次体存在下的代谢方面，以及这种存在如何引发炎症反应来应对病原体。我们还回顾了细胞因子的分泌，这些细胞因子在免疫和代谢水平上调节宿主细胞的反应。
