哇巴因对基础状态及甲状腺激素刺激的肌肉耗氧量的影响。
The effect of ouabain on basal and thyroid hormone-stimulated muscle oxygen consumption.
作者信息
Wardlaw G M
出版信息
Int J Biochem. 1986;18(3):279-81. doi: 10.1016/0020-711x(86)90119-9.
PMID:3007233
Abstract
In vivo triiodothyronine treatment (T3) increased soleus muscle oxygen consumption (QO2) when measured in vitro. Ouabain significantly decreased T3-induced muscle QO2, but not basal muscle QO2. Ouabain-sensitive metabolic processes in muscle, which essentially represents Na-K-ATPase activity, accounted for approximately 85% of the increased energy utilization by muscles that was caused by T3 treatment.
摘要
体内三碘甲状腺原氨酸治疗（T3）可使离体测量时比目鱼肌的氧消耗量（QO2）增加。哇巴因可显著降低T3诱导的肌肉QO2，但对基础肌肉QO2无影响。肌肉中对哇巴因敏感的代谢过程，主要代表钠钾ATP酶活性，约占T3治疗引起的肌肉能量利用增加量的85%。
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