Macroscopic Chiral Recognition by Calix[4]arene-Based Host-Guest Interactions.

Chiral recognition as an intrinsic process of life, plays a crucial role in chemical systems, and further forms various architectures in the resulted functional materials. So far, relevant studies were focused on the recognition of chiral molecules. However, weak chiral interactions transformed into macroscopic recognition, for example, for chiral drug droplets, is much more crucial due to its applicability in controlling the drugs' selective delivery and for their enantiomer separation. In this report, chiral calix[4]arene was introduced onto a surface for the selective recognition of (S)-naproxen droplet through host-guest interactions.