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从搏动性心尖向心性收缩到有效的上皮力学。

From pulsatile apicomedial contractility to effective epithelial mechanics.

机构信息

Department Physiology, Development and Neuroscience, Univ. Cambridge, Cambridge, United Kingdom.

LIPHY, Univ. Grenoble Alpes, Grenoble, France; LIPHY, CNRS, Grenoble, France.

出版信息

Curr Opin Genet Dev. 2018 Aug;51:78-87. doi: 10.1016/j.gde.2018.07.004. Epub 2018 Aug 1.

Abstract

We review recent developments in the understanding of the biomechanics of apicomedial actomyosin and how its contractility can tense and deform tissue. Myosin pulses are driven by a biochemical oscillator but how they are modulated by the mechanical context remains unclear. On the other hand, the emergence of tissue behaviour is highly dependent on the material properties of actin, on how strongly components are connected and on the influence of neighbouring tissues. We further review the use of constitutive equations in exploring the mechanics of epithelial apices dominated by apicomedial Myosin contractility.

摘要

我们回顾了近年来对顶端中侧肌动球蛋白生物力学的理解的发展,以及它的收缩能力如何使组织紧张和变形。肌球蛋白脉冲由生化振荡器驱动,但机械环境如何调节它们仍不清楚。另一方面,组织行为的出现高度依赖于肌动蛋白的材料特性,组件连接的紧密程度以及相邻组织的影响。我们还回顾了在探索由顶端中侧肌球蛋白收缩主导的上皮顶端力学中本构方程的应用。

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