Yin Shuai, Chen Fang-Fang, Yang Gui-Fang
Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Pathol Res Pract. 2018 Sep;214(9):1376-1380. doi: 10.1016/j.prp.2018.07.014. Epub 2018 Jul 25.
The prognostic value of vimentin expression in Gastric Cancer (GC) has been assessed for years while the results are still in dispute. Thus, we performed a meta-analysis to determine the effect of vimentin immunohistochemical (IHC) expression on the prognosis of GC.
Literature searches were performed in PubMed and Embase. The meta-analysis examined the association of vimentin IHC expression with prognosis and clinicopathological characteristics of GC patients.
In total, ten studies involving 1598 cases were enrolled in this meta-analysis. Vimentin positive expression was significantly correlated with poor overall survival (OS) in GC patients (HR = 2.05, 95% CI: 1.29-3.24) but there was a significant degree of heterogeneity (I = 77%, P = 0.0006). Subgroup analysis indicated that vimentin expression had an unfavorable impact on OS in Chinese patients (HR = 2.43, 95% CI: 1.30-4.55). Moreover, vimentin positive expression rates was significantly associated with age, tumor location, TNM stage and lymph node metastasis. However, vimentin positive expression rates did not correlate with gender, grade of differentiation, vascular invasion, the depth of invasion, hepatic metastasis or peritoneal metastasis.
Positive vimentin expression could serve as a poor prognostic marker in GC.
多年来一直在评估波形蛋白表达在胃癌（GC）中的预后价值，但结果仍存在争议。因此，我们进行了一项荟萃分析，以确定波形蛋白免疫组化（IHC）表达对GC预后的影响。
在PubMed和Embase中进行文献检索。荟萃分析考察了波形蛋白IHC表达与GC患者预后及临床病理特征之间的关联。
本荟萃分析共纳入10项研究，涉及1598例病例。波形蛋白阳性表达与GC患者较差的总生存期（OS）显著相关（HR = 2.05，95%CI：1.29 - 3.24），但存在显著的异质性（I = 77%，P = 0.0006）。亚组分析表明，波形蛋白表达对中国患者的OS有不利影响（HR = 2.43，95%CI：1.30 - 4.55）。此外，波形蛋白阳性表达率与年龄、肿瘤位置、TNM分期和淋巴结转移显著相关。然而，波形蛋白阳性表达率与性别、分化程度、血管侵犯、浸润深度、肝转移或腹膜转移无关。
波形蛋白阳性表达可作为GC预后不良的标志物。
