Dinas Petros C, Nintou Eleni, Psychou Dimitra, Granzotto Marnie, Rossato Marco, Vettor Roberto, Jamurtas Athanasios Z, Koutedakis Yiannis, Metsios George S, Flouris Andreas D
FAME Laboratory, Department of Exercise Science, University of Thessaly, Trikala, Greece.
Institute of Sport, Faculty of Education Health and Wellbeing, University of Wolverhampton, Walsall, UK.
F1000Res. 2018 Mar 15;7:327. doi: 10.12688/f1000research.14198.2. eCollection 2018.
Atrial natriuretic peptide increases lipolysis in human adipocytes by binding to natriuretic peptide receptor-A (NPRA). The aim of the current study was to examine the associations of NPRA mRNA of subcutaneous adipose tissue with fat mass, fat-free mass, body mass index (BMI) and arterial blood pressure in medication-free healthy men. Thirty-two volunteers [age (years): 36.06±7.36, BMI: 27.60±4.63 (kg/m )] underwent assessments of body height/weight, % fat mass, fat-free mass (kg), blood pressure, and a subcutaneous adipose tissue biopsy via a surgical technique. We found that NPRA mRNA was negatively associated with % fat mass (r=-0.40, R =0.16, p=0.03) and BMI (r=-0.45, R =0.20, p=0.01). Cohen's effect size analyses showed a small effect size between NPRA mRNA and BMI ( =0.25). One-way analysis of variance with Bonferroni post-hoc tests showed a tendency for mean differences of NPRA mRNA across BMI categories (p=0.06). This was confirmed by Cohen's effect size analyses revealing a large effect size of NPRA mRNA between obese individuals (BMI≥30 kg/m ) and either normal weight (BMI=19-25 kg/m ; =0.94) or overweight (BMI=25-30 kg/m ; =1.12) individuals. NPRA mRNA is negatively associated with % fat mass and BMI in medication-free healthy men, suggesting a possible role of NPRA in the control of fat mass accumulation.
心房利钠肽通过与利钠肽受体-A（NPRA）结合来增加人类脂肪细胞的脂肪分解。本研究的目的是在未服用药物的健康男性中，检测皮下脂肪组织的NPRA mRNA与脂肪量、去脂体重、体重指数（BMI）和动脉血压之间的关联。32名志愿者[年龄（岁）：36.06±7.36，BMI：27.60±4.63（kg/m²）]接受了身高/体重、脂肪量百分比、去脂体重（kg）、血压评估，并通过手术技术进行了皮下脂肪组织活检。我们发现NPRA mRNA与脂肪量百分比（r = -0.40，R² = 0.16，p = 0.03）和BMI（r = -0.45，R² = 0.20，p = 0.01）呈负相关。Cohen效应量分析显示NPRA mRNA与BMI之间的效应量较小（d = 0.25）。采用Bonferroni事后检验的单因素方差分析显示，NPRA mRNA在不同BMI类别中的均值差异有一定趋势（p = 0.06）。Cohen效应量分析证实了这一点，该分析显示肥胖个体（BMI≥30 kg/m²）与正常体重个体（BMI = 19 - 25 kg/m²；d = 0.94）或超重个体（BMI = 25 - 30 kg/m²；d = 1.12）之间NPRA mRNA的效应量较大。在未服用药物的健康男性中，NPRA mRNA与脂肪量百分比和BMI呈负相关，提示NPRA在控制脂肪量积累中可能发挥作用。
