Child R G, Osterberg A C, Sloboda A E, Tomcufcik A S
J Pharm Sci. 1977 Apr;66(4):466-76. doi: 10.1002/jps.2600660403.
One hundred analogs of fenbufen were prepared and tested using the carrageenan, polyarthritis, and UV erythema anti-inflammatory tests and the 2-phenyl-1,4-benzoquinone writhing and inflamed paw pressure analgesic tests. Only three retained the same full spectrum of activity as fenbufen: dl-4-(4-biphenylyl)-4-hydroxybutyric acid, dl-4-(4-biphenylyl)-1,4-butanediol, and 4-biphenylacetic acid. Fenbufen had the same spectrum of activity as aspirin, phenylbutazone, and indomethacin in the five tests. In addition, dose-response derived potencies show fenbufen more potent than aspirin and at least as potent as phenylbutazone in all five tests. Two related compounds were generally similar.
制备了100种芬布芬类似物，并通过角叉菜胶、多关节炎和紫外线红斑抗炎试验以及2-苯基-1,4-苯醌扭体和炎性爪压力镇痛试验进行测试。只有三种化合物保留了与芬布芬相同的全谱活性：dl-4-(4-联苯基)-4-羟基丁酸、dl-4-(4-联苯基)-1,4-丁二醇和4-联苯乙酸。在这五项试验中，芬布芬与阿司匹林、保泰松和吲哚美辛具有相同的活性谱。此外，剂量反应得出的效价表明，在所有五项试验中，芬布芬比阿司匹林更有效，且至少与保泰松一样有效。两种相关化合物通常相似。
