Patel S, Millan M H, Mello L M, Meldrum B S
Neurosci Lett. 1986 Feb 28;64(2):226-30. doi: 10.1016/0304-3940(86)90105-9.
Motor limbic seizures occur following a systemic injection of pilocarpine (380 mg/kg) in rats. Focal injection of the selective N-methyl-D-aspartate receptor antagonist, (+/-)-2-amino-7-phosphonoheptanoic acid (2-APH, 5-20 pmol), bilaterally into the entopeduncular nucleus (EP) prior to pilocarine blocks these seizures. Muscimol (50 pmol), a potent gamma-aminobutyric acid receptor agonist, injected bilaterally into EP produces a similar protection against pilocarpine-induced seizures. Thus by blocking excitatory neurotransmission or facilitating inhibition within the EP, the severity of limbic seizures can be reduced.
在给大鼠全身注射毛果芸香碱（380毫克/千克）后会出现运动性边缘叶癫痫发作。在注射毛果芸香碱之前，双侧向脚内核（EP）局部注射选择性N-甲基-D-天冬氨酸受体拮抗剂（±）-2-氨基-7-磷酸庚酸（2-APH，5-20皮摩尔）可阻断这些癫痫发作。向EP双侧注射强效γ-氨基丁酸受体激动剂蝇蕈醇（50皮摩尔），对毛果芸香碱诱发的癫痫发作也有类似的保护作用。因此，通过阻断EP内的兴奋性神经传递或促进抑制作用，可以减轻边缘叶癫痫发作的严重程度。
