Maslova L N, Lur'e S B, Lukina T A, Reshenin A M, Naumenko E V
Ontogenez. 1986 Jan-Feb;17(1):56-61.
The effects of hormone action and disturbance in catecholamine synthesis in the early postnatal ontogenesis on the circadian rhythm in the hypothalamic-hypophysial-adrenocortical system function were compared in the adult albino rat males. Injection of prednisolone on the 17-19th days of life blocked completely the diurnal rhythm of the corticosterone basal level in blood, the rhythm of adrenocortical response to an emotional stressor and to injection of noradrenaline into the brain lateral ventricle in 3-4 month old animals. Injection of an inhibitor of tyrosine hydroxylase, alpha-methyl-p-tyrosine, at the same period resulted in disappearance of the diurnal rhythm of the corticosterone basal level in adult animals, although the rhythm of response to an emotional stressor or injection of noradrenaline into the brain remained unchanged. A conclusion has been reached that disturbances in catecholamine synthesis in the early postnatal period induces long-term changes of predominantly tonic corticosterone secretion, while the hormone action on the circadian rhythm of the corticosterone basal level and stress response is only partly due to changes in noradrenergic regulation of the hypothalamic-hypophysial-adrenocortical system.
在成年雄性白化大鼠中，比较了出生后早期发育过程中激素作用和儿茶酚胺合成紊乱对下丘脑 - 垂体 - 肾上腺皮质系统功能昼夜节律的影响。在出生后第17 - 19天注射泼尼松龙，完全阻断了3 - 4月龄动物血液中皮质酮基础水平的昼夜节律、肾上腺皮质对情绪应激源以及向脑侧脑室注射去甲肾上腺素的反应节律。在同一时期注射酪氨酸羟化酶抑制剂α - 甲基 - p - 酪氨酸，导致成年动物皮质酮基础水平的昼夜节律消失，尽管对情绪应激源或向脑内注射去甲肾上腺素的反应节律保持不变。得出的结论是，出生后早期儿茶酚胺合成的紊乱会导致主要是皮质酮紧张性分泌的长期变化，而激素对皮质酮基础水平昼夜节律和应激反应的作用仅部分归因于下丘脑 - 垂体 - 肾上腺皮质系统去甲肾上腺素能调节的变化。
