Department of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Cell Commun Signal. 2018 Aug 6;16(1):44. doi: 10.1186/s12964-018-0255-9.
The Rab27 family of small GTPases promotes the progression of breast cancer, melanoma, and other human cancers. In this review, we discuss the role of Rab27 GTPases in cancer progression and the potential applications of these targets in cancer treatment.
Elevated expression of Rab27 GTPases is associated with poor prognosis and cancer metastasis. Moreover, these GTPases govern a variety of oncogenic functions, including cell proliferation, cell motility, and chemosensitivity. In addition, small GTPases promote tumor growth and metastasis by enhancing exosome secretion, which alters intracellular microRNA levels, signaling molecule expression, and the tumor microenvironment.
Rab27 GTPases may have applications as prognostic markers and therapeutic targets in cancer treatment.
Rab27 家族的小分子 GTPases 促进了乳腺癌、黑色素瘤和其他人类癌症的进展。在这篇综述中，我们讨论了 Rab27 GTPases 在癌症进展中的作用以及这些靶点在癌症治疗中的潜在应用。
Rab27 GTPases 的高表达与不良预后和癌症转移有关。此外，这些 GTPases 控制着各种致癌功能，包括细胞增殖、细胞迁移和化疗敏感性。此外，小分子 GTPases 通过增强外泌体分泌来促进肿瘤生长和转移，从而改变细胞内 microRNA 水平、信号分子表达和肿瘤微环境。
Rab27 GTPases 可能作为癌症治疗中的预后标志物和治疗靶点得到应用。
