Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, UK.
Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, UK.
Trends Parasitol. 2018 Sep;34(9):735-746. doi: 10.1016/j.pt.2018.07.001. Epub 2018 Aug 3.
Malaria remains a major global health challenge. Appropriate use of current antimalarial tools has reduced the disease burden, but morbidity and mortality remain unacceptably high. It is widely accepted that, to achieve long-term control/eradication, it will be necessary to use interventions that inhibit the transmission of parasites to mosquitoes - these tools are termed transmission-blocking interventions (TBIs). This article aims to outline the rationale for the development of TBIs, with a focus on transmission-blocking drugs and (parasite-derived) transmission-blocking vaccines. We describe and summarise the current status of each of these intervention classes and attempt to identify future requirements in development, with a focus on the challenges of establishing each method within an integrated malarial control programme in the future.
疟疾仍然是一个重大的全球健康挑战。当前抗疟工具的合理使用已经减轻了疾病负担，但发病率和死亡率仍然高得不可接受。人们普遍认为，要实现长期控制/消除疟疾，就必须使用抑制寄生虫向蚊子传播的干预措施——这些工具被称为阻断传播干预措施（TBIs）。本文旨在概述开发 TBIs 的基本原理，重点介绍阻断传播的药物和（寄生虫来源的）阻断传播疫苗。我们描述和总结了这些干预类别的当前现状，并试图确定未来的开发需求，重点是在未来的综合疟疾控制计划中确定每种方法的挑战。
