Waldmann T A
Science. 1986 May 9;232(4751):727-32. doi: 10.1126/science.3008337.
Antigen or mitogen-induced activation of resting T cells induces the synthesis of interleukin-2 (IL-2) as well as the expression of specific cell surface receptors for this lymphokine. Failure of the production of either IL-2 or its receptor results in a failure of the T-cell immune response. The receptor is composed of a 33,000-dalton (251-amino acid) peptide precursor that is post-translationally glycosylated into the mature 55,000-dalton form. In contrast to resting T cells, human T-cell lymphotrophic virus I (HTLV-I)-associated adult T-cell leukemia cells constitutively express large numbers of IL-2 receptors. Because IL-2 receptors are present on the malignant T cells but not on normal resting cells, clinical trials have been initiated in which patients with adult T-cell leukemia are treated with a monoclonal antibody that binds to the IL-2 receptor.
抗原或丝裂原诱导静息T细胞活化，可诱导白细胞介素-2（IL-2）的合成以及该淋巴因子特异性细胞表面受体的表达。IL-2或其受体产生失败会导致T细胞免疫反应失败。该受体由一个33000道尔顿（251个氨基酸）的肽前体组成，该前体在翻译后被糖基化成为成熟的55000道尔顿形式。与静息T细胞不同，人类T细胞嗜淋巴细胞病毒I（HTLV-I）相关的成人T细胞白血病细胞组成性表达大量IL-2受体。由于IL-2受体存在于恶性T细胞而非正常静息细胞上，因此已经启动了临床试验，用与IL-2受体结合的单克隆抗体治疗成人T细胞白血病患者。
