Karabulut Nuran, Alacam Sema, Yolcu Ayfer, Onel Mustafa, Agacfidan Ali
Department of Medical Microbiology, Division of Virology and Fundamental Immunology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Indian J Med Microbiol. 2018 Apr-Jun;36(2):192-196. doi: 10.4103/ijmm.IJMM_17_381.
The hepatitis C virus (HCV) has seven main genotypes and multiple subtypes. The distribution of HCV genotypes varies across geographical regions worldwide. Updated estimates of HCV genotype distributions have a critical importance for developing strategies to manage or eliminate HCV infection. The aim of this study was to determine the distribution of HCV genotypes in patients with HCV admitted to a university hospital in Istanbul, Turkey.
A total of 412 HCV RNA positive patients with 46.6% of males and 53.4% of females between January 2013 and September 2016 were included in the study. Genotyping of HCV of the study population was performed by a commercial reverse hybridisation line probe-based assay.
Genotype 1 (82.5%) was dominant genotype, followed by genotype 3 (10.7%), genotype 2 (4.6%) and genotype 4 (2.2%). Among patients with genotype 1, subtype 1a, 1b and undetermined subtype were 6.3%, 38.8% and 37.4%, respectively. It was observed that genotype proportion was dependent on gender and age of the patients. Genotype 1 and genotype 2 were more prevalent in females, whereas genotypes 3 and 4 were more prevalent in males. Genotype 1 in the older patients and genotype 3 in the younger patients were more prevalent.
The majority of patients with HCV infection had genotype 1 (82.5%), followed by genotype 3, 2 and 4. Monitoring the change in HCV genotype distribution is critical for the development of effective strategies for HCV elimination.
丙型肝炎病毒（HCV）有七种主要基因型和多种亚型。HCV基因型的分布在全球不同地理区域有所不同。更新HCV基因型分布的估计值对于制定管理或消除HCV感染的策略至关重要。本研究的目的是确定在土耳其伊斯坦布尔一家大学医院就诊的HCV患者中HCV基因型的分布情况。
本研究纳入了2013年1月至2016年9月期间共412例HCV RNA阳性患者，其中男性占46.6%，女性占53.4%。研究人群的HCV基因分型通过基于商业反向杂交线探针的检测方法进行。
基因型1（82.5%）是主要基因型，其次是基因型3（10.7%）、基因型2（4.6%）和基因型4（2.2%）。在基因型1的患者中，亚型1a、1b和未确定亚型分别占6.3%、38.8%和37.4%。观察到基因型比例取决于患者的性别和年龄。基因型1和基因型2在女性中更普遍，而基因型3和4在男性中更普遍。老年患者中基因型1更普遍，年轻患者中基因型3更普遍。
大多数HCV感染患者为基因型1（82.5%），其次是基因型3、2和4。监测HCV基因型分布的变化对于制定有效的HCV消除策略至关重要。
