Hosseinirad Hossein, Rashidi Mohsen, Moghaddam Mehrdad Moosazadeh, Tebyanian Hamid, Nouraei Soheila, Mirhosseini Seyed Ali, Rasouli Mehdi, Habibian Soheil
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Faculty of Medicine, Mazandaran University of Medical Sciences Department of Physiology and Pharmacology, Sari Iran.
Cell Mol Biol (Noisy-le-grand). 2018 Jul 30;64(10):92-101.
The respiratory system is a complex group of organs in the human body, all of which are necessary in breathing. Due to its special anatomy and composition, after exposure to various damaging factors such as micro particles, carbon granules and toxic gases, the respiratory system can be affected by a variety of damage without return to its original state. Currently, the prevalence of lung diseases, including asthma, and chronic obstructive pulmonary diseases, such as emphysema, has increased remarkably. New therapeutic approaches are desperately needed to discover regenerative medicine approaches, especially cell therapy. This review summarizes the recent advances in stem cell treatments and the research efforts conducted through the application of stem cell therapy for respiratory system diseases. In particular, researchers have used animal models to gather data about treating lung injury by stem cell transplantation. This review concentrated on the findings about route, timing and adjustment of cell transplantation dose, optimum stem cell type selection and potency marker of cells as therapeutic agents. These factors are essential subjects for approval and clinical transplantation. The current clinical trials aiming at treatment of lung diseases by stem cells are mentioned and discussed.
呼吸系统是人体中一组复杂的器官，所有这些器官在呼吸过程中都是必需的。由于其特殊的解剖结构和组成，在接触各种有害因素，如微粒、碳颗粒和有毒气体后，呼吸系统会受到各种损害且无法恢复到原始状态。目前，包括哮喘在内的肺部疾病以及诸如肺气肿等慢性阻塞性肺疾病的患病率显著增加。迫切需要新的治疗方法来探索再生医学方法，尤其是细胞疗法。本综述总结了干细胞治疗的最新进展以及通过应用干细胞疗法治疗呼吸系统疾病所开展的研究工作。特别是，研究人员利用动物模型收集有关通过干细胞移植治疗肺损伤的数据。本综述重点关注细胞移植的途径、时机和剂量调整、最佳干细胞类型选择以及作为治疗剂的细胞效能标志物等方面的研究结果。这些因素是获批和临床移植的关键主题。文中提及并讨论了目前旨在通过干细胞治疗肺部疾病的临床试验。
