Verhagen J, Bruynzeel P L
Allergol Immunopathol (Madr). 1985 Nov-Dec;13(6):531-7.
Six years ago the structure of slow reacting substance of anaphylaxis (SRS-A), a strongly bronchoconstrictive substance, has been unravelled SRS-A proved to be a mixture of different closely related compounds, now denominated as sulfidopeptide Leukotrienes. Leukotrienes possess a conjugated triene system and one or more oxygen functions. They are formed from membrane derived arachidonic acid by an initial oxygenation by the enzyme lipoxygenase. Sofar the following leukotrienes have been characterized leukotriene A4, B4, C4, D4, E4 and F4. Leukotrienes possess important biological properties. Leukotriene B4 is strongly chemotactic for leukocytes, whereas the sulfidopeptide leukotrienes C4, D4 and E4 are strongly spasmogenic. In this review the formation and the different biological activities of leukotrienes and the possible role of leukotrienes in the asthmatic process will be discussed.
六年前，过敏反应慢反应物质（SRS-A）——一种强效支气管收缩物质——的结构被解析出来。结果证明，SRS-A是不同的密切相关化合物的混合物，现在被命名为硫化肽白三烯。白三烯具有一个共轭三烯系统和一个或多个氧官能团。它们由膜衍生的花生四烯酸通过脂氧合酶的初始氧化作用形成。到目前为止，已鉴定出以下白三烯：白三烯A4、B4、C4、D4、E4和F4。白三烯具有重要的生物学特性。白三烯B4对白细胞具有强烈的趋化作用，而硫化肽白三烯C4、D4和E4则具有强烈的致痉挛作用。在这篇综述中，将讨论白三烯的形成、不同的生物学活性以及白三烯在哮喘过程中可能发挥的作用。
