Department of Human Genetics, McGill University, Canada; The Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
Department of Human Genetics, McGill University, Canada; The Research Institute of the McGill University Health Centre, Montréal, Québec, Canada; Department of Pediatrics, McGill University, Canada.
Reprod Toxicol. 2018 Oct;81:155-167. doi: 10.1016/j.reprotox.2018.08.008. Epub 2018 Aug 4.
The cause and effect relationship between environmental factors, including toxins (naturally occuring) and toxicants (man-made environmental contaminants), and neural tube defects is well-established. More recent evidence has demonstrated a requirement for the claudin family of tight junction proteins in regulating epithelial remodelling events that transform the plate neural plate into a closed tube. At the molecular level, toxicants are known to disrupt claudin expression and tight junction barrier function. In this review we consider the evidence leading to the hypothesis that toxins and toxicants affect neural tube closure due to their effects on the claudin family of tight junction proteins.
环境因素（包括毒素（天然存在的）和有毒物质（人为的环境污染物））与神经管缺陷之间的因果关系已得到充分确立。最近的证据表明，紧密连接蛋白家族 Claudin 在调节上皮重塑事件中具有重要作用，这些事件将基板神经管转化为封闭的管状结构。在分子水平上，已知有毒物质会破坏 Claudin 的表达和紧密连接的屏障功能。在这篇综述中，我们考虑了导致假设的证据，即由于它们对紧密连接蛋白家族 Claudin 的影响，毒素和有毒物质会影响神经管闭合。
