Sensor Visions AB, Legendgatan 116, 422 55 Hisings Backa, Sweden.
Department of Micro- and Nanotechnology, DNRF and Villum Fonden Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, IDUN, Technical University of Denmark, Ørsteds Plads, 2800 Kgs. Lyngby, Denmark.
Talanta. 2018 Nov 1;189:649-652. doi: 10.1016/j.talanta.2018.07.009. Epub 2018 Jul 10.
Ultra-sensitive in-field measurements of most forensic substances still today remain a challenge for first responders and forensic investigators. Handheld Raman spectroscopy equipment is getting more and more routinely used in the field for evidence collection, however, restricted to measurements of pure or high concentration samples. Here, surface-enhanced Raman scattering (SERS) sensing of common forensic substances with commercially available SERS substrates and handheld spectrometers, have been investigated. 3D Finite Element Method (FEM) and Density Functional Theory (DFT) simulations were used to interpret the high SERS enhancement of the Ag nanopillar substrate and the detection of the substances, respectively. The forensic generality and high performance of the analytical method were demonstrated by explicit detection of close to unprecedented amounts, down to femtograms, of Cyclosarin, RDX, Amphetamine and Picric acid. Implications are ultra-sensitive in-field SERS detection of these substances with commercial equipment.
目前，对于一线响应人员和法医调查人员来说，对大多数法医物质进行超灵敏现场测量仍然是一个挑战。手持式拉曼光谱仪设备越来越多地在现场用于证据收集，但仅限于对纯物质或高浓度样品进行测量。本研究调查了使用市售 SERS 基底和手持式光谱仪对常见法医物质的表面增强拉曼散射（SERS）传感。使用三维有限元方法（FEM）和密度泛函理论（DFT）模拟分别来解释 Ag 纳米柱基底的高 SERS 增强和物质的检测。通过明确检测到接近前所未有的环沙林、黑索金、苯丙胺和苦味酸的皮克数量（飞克级），证明了该分析方法的法医通用性和高性能。这意味着可以使用商业设备对这些物质进行超灵敏的现场 SERS 检测。
