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坏血病:营养充足的第一世界仍面临威胁?

Scurvy: still a threat in the well-fed first world?

机构信息

University Department of Pediatrics, Bambino Gesù Children's Hospital, University of Rome Tor Vergata, Rome, Italy.

General Pediatric and Infectious Disease Unit, University Department of Pediatrics, Bambino Gesù Children's Hospital, Rome, Italy.

出版信息

Arch Dis Child. 2019 Apr;104(4):381-383. doi: 10.1136/archdischild-2018-315496. Epub 2018 Aug 7.

Abstract

We report three cases of scurvy in previously healthy children referred to us for leg pain and refusal to walk. All children had no significant medical history, symptoms had started months before and subtly advanced. Two of them presented with gingival hyperplasia and petechiae, another one reported night sweats and gingival bleeding in the past few weeks. Two had vitamin D deficiency, and all had microcytic anaemia (in one case requiring transfusional support). A nutritional screening revealed low or undetectable levels of ascorbic acid. This, along with the clinical and radiological findings, led to a diagnosis of scurvy. Vitamin C supplementation was started with rapid improvement of the children's clinical condition. Scurvy is a rare disease in the 'first world', but there are anecdotal reports of scurvy in children without any of the known risk factors for this condition. In our cases, a selective diet was the only risk factor.

摘要

我们报告了三例坏血病病例,这些患儿均为之前身体健康,因腿部疼痛和拒绝行走而被转介至我们处。所有患儿均无重大病史,症状在数月前开始出现,并逐渐加重。其中 2 例患儿有牙龈增生和瘀斑,另 1 例患儿在过去几周内出现夜间盗汗和牙龈出血。其中 2 例患儿维生素 D 缺乏,所有患儿均有小细胞性贫血(1 例需要输血支持)。营养筛查显示抗坏血酸水平低或无法检测到。这与临床和影像学发现一起导致了坏血病的诊断。开始补充维生素 C 后,患儿的临床状况迅速改善。坏血病在“第一世界”很少见,但有一些关于无任何已知该病危险因素的儿童患坏血病的零星报告。在我们的病例中,选择性饮食是唯一的危险因素。

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