Cheng Jiwen, Zhuo Zhenjian, Xin Yijuan, Zhao Pu, Yang Weili, Zhou Haixia, Zhang Jiao, Gao Ya, He Jing, Li Peng
Department of Pediatric Surgery, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China.
School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China.
Aging (Albany NY). 2018 Aug 8;10(8):1989-2000. doi: 10.18632/aging.101522.
Neuroblastoma is a lethal tumor that commonly occurs in children. Polymorphisms in reportedly influence risk for several types of cancer, though their roles in neuroblastoma remain unclear. Here we endeavored to determine the relevance of gene polymorphisms and neuroblastoma susceptibility in Chinese children genotyping three polymorphisms (rs3810366, rs13181 and rs238406) in 505 cases and 1070 controls and assessing their contributions to neuroblastoma risk. Overall, we detected no significant association between any single genotype and neuroblastoma risk. When risk genotypes were combined, however, we found that patients with 2-3 risk genotypes were more likely to develop neuroblastoma (adjusted odds ratio =1.31; 95% confidence interval =1.06-1.62, =0.013) than those with 0-1 risk genotypes. Stratification analysis of rs3810366 revealed significant relationships between the subgroups age ≤18 months and clinical stage I+II+4s and neuroblastoma risk. Moreover, the presence of 2-3 risk genotypes was significantly associated with increased neuroblastoma risk in the subgroups age ≤18 months, male, tumor originated from others, and clinical stage I+II+4s. Our findings provide novel insight into the genetic underpinnings of neuroblastoma and demonstrate that polymorphisms may have a cumulative effect on neuroblastoma risk.
神经母细胞瘤是一种常见于儿童的致命性肿瘤。据报道，[基因名称]中的多态性会影响多种癌症的发病风险，但其在神经母细胞瘤中的作用尚不清楚。在此，我们对505例病例和1070例对照进行了三种多态性（rs3810366、rs13181和rs238406）的基因分型，并评估它们对神经母细胞瘤风险的影响，以确定[基因名称]基因多态性与中国儿童神经母细胞瘤易感性之间的相关性。总体而言，我们未发现任何单一基因型与神经母细胞瘤风险之间存在显著关联。然而，当将风险基因型合并时，我们发现具有2 - 3种风险基因型的患者比具有0 - 1种风险基因型的患者更易患神经母细胞瘤（校正比值比 = 1.31；95%置信区间 = 1.06 - 1.62，P = 0.013）。对rs3810366的分层分析显示，年龄≤18个月的亚组以及临床分期I + II + 4s与神经母细胞瘤风险之间存在显著关系。此外，在年龄≤18个月、男性、肿瘤起源于其他部位以及临床分期I + II + 4s的亚组中，存在2 - 3种风险基因型与神经母细胞瘤风险增加显著相关。我们的研究结果为神经母细胞瘤的遗传基础提供了新的见解，并表明[基因名称]多态性可能对神经母细胞瘤风险具有累积效应。
